炎症血液标志物作为接受新辅助化疗的早期乳腺癌患者的预后和预测因素
Inflammatory Blood Markers as Prognostic and Predictive Factors in Early Breast Cancer Patients Receiving Neoadjuvant Chemotherapy.
作者信息
Corbeau Ileana, Thezenas Simon, Maran-Gonzalez Aurelie, Colombo Pierre-Emmanuel, Jacot William, Guiu Severine
机构信息
Department of Medical Oncology, Institut du Cancer de Montpellier (ICM), Parc Euromedecine, 208 avenue des apothicaires, 34 298 Montpellier, France.
Institut de Recherche en Cancerologie de Montpellier, INSERM U1194, University of Montpellier, ICM Parc Euromedecine, 208 Avenue des Apothicaires, 34 298 Montpellier, France.
出版信息
Cancers (Basel). 2020 Sep 18;12(9):2666. doi: 10.3390/cancers12092666.
BACKGROUND
Inflammatory blood markers, such as neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), have been reported as putative prognostic factors for survival and predictive factors for pathological complete response and toxicity in cancers, however with conflicting results.
METHODS
We retrospectively analyzed data of 280 patients with early breast cancer receiving neo-adjuvant chemotherapy between 2005 and 2013 in our center. Neutrophil count, lymphocyte count and platelet count before treatment were collected as well as data on pathological complete response, toxicity, recurrence and survival.
RESULTS
In multivariate analysis, high PLR was an independent prognostic factor for relapse-free survival (hazard ratio [HR] = 1.91; 95%CI = 1.15-3.16; = 0.012) and for shorter overall survival (HR = 1.83; 95%CI = 1.03-3.24; = 0.039). NLR was an independent predictive factor for febrile neutropenia (HR = 0.28; 95%CI = 0.13-0.58; = 0.001). In triple negative breast cancer molecular subtype, low white blood cell count (<6.75 G/L) was predictive for a higher pathological complete response rate (odds ratio [OR] = 0.29; 95%CI = 0.14-0.61; < 0.01).
CONCLUSION
In the present study, PLR was found as an independent prognostic factor for survival, while NLR was an independent predictive factor for febrile neutropenia.
背景
炎症血液标志物，如中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR），已被报道为癌症生存的假定预后因素以及病理完全缓解和毒性的预测因素，然而结果相互矛盾。
方法
我们回顾性分析了2005年至2013年在本中心接受新辅助化疗的280例早期乳腺癌患者的数据。收集治疗前的中性粒细胞计数、淋巴细胞计数和血小板计数以及病理完全缓解、毒性、复发和生存数据。
结果
在多变量分析中，高PLR是无复发生存的独立预后因素（风险比[HR]=1.91；95%置信区间=1.15-3.16；P=0.012）以及总生存期较短的独立预后因素（HR=1.83；95%置信区间=1.03-3.24；P=0.039）。NLR是发热性中性粒细胞减少的独立预测因素（HR=0.28；95%置信区间=0.13-0.58；P=0.001）。在三阴性乳腺癌分子亚型中，低白细胞计数（<6.75 G/L）预测更高的病理完全缓解率（优势比[OR]=0.29；95%置信区间=0.14-0.61；P<0.01）。
结论
在本研究中，PLR被发现是生存的独立预后因素，而NLR是发热性中性粒细胞减少的独立预测因素。
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