Iheanacho Stanley Chidi, Igberi Christiana, Amadi-Eke Akunna, Chinonyerem Delight, Iheanacho Angus, Avwemoya Fred
Department of Fisheries and Aquaculture, Alex Ekwueme Federal University Ndufu Alike, Ikwo, Nigeria.
Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Nigeria.
Biomarkers. 2020 Nov;25(7):603-610. doi: 10.1080/1354750X.2020.1821777. Epub 2020 Sep 22.
Plastic particulates and chemicals are emerging environmental pollutants with significant impact on aquatic ecosystems. In this study, the effects of oral uptake of melamine, melamine formaldehyde, and polyvinyl chloride on serum biochemical profiles, antioxidant enzymes activities, lipid peroxidation levels and brain acetyl cholinesterase activities in juveniles were investigated.
Fish specimens were fed diets spiked with melamine, melamine formaldehyde and poly vinyl chloride at 0.3% (3.0 g Kg) dietary inclusion for 45 days. Toxicity effect of these plastic chemicals was estimated by assaying relevant biomarkers.
After 45 days exposure, Serum glucose was significantly elevated, whereas plasma protein levels were substantially reduced in the exposed fish groups. Serum transaminases were significantly elevated in the exposed groups. Brain acetylcholinesterase and antioxidant enzyme activities declined significantly, while malondialdehyde levels were elevated in the exposed groups.
is an important bioindicator to monitor the ecotoxicological impact of plastic chemicals such as melamine, and polyvinyl chloride.
塑料微粒和化学物质是新兴的环境污染物，对水生生态系统有重大影响。本研究调查了幼鱼口服三聚氰胺、三聚氰胺甲醛和聚氯乙烯对其血清生化指标、抗氧化酶活性、脂质过氧化水平及脑乙酰胆碱酯酶活性的影响。
将鱼标本投喂添加了0.3%（3.0 g Kg）三聚氰胺、三聚氰胺甲醛和聚氯乙烯的饲料，持续45天。通过检测相关生物标志物来评估这些塑料化学物质的毒性效应。
暴露45天后，暴露组鱼的血清葡萄糖显著升高，而血浆蛋白水平大幅降低。暴露组血清转氨酶显著升高。脑乙酰胆碱酯酶和抗氧化酶活性显著下降，而暴露组丙二醛水平升高。
是监测三聚氰胺和聚氯乙烯等塑料化学物质生态毒理学影响的重要生物指标。
