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间歇性低氧可减少急性心肌梗死大鼠的梗死面积：系统评价和荟萃分析。

Intermittent hypoxia reduces infarct size in rats with acute myocardial infarction: a systematic review and meta-analysis.

机构信息

Department of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, No. 74, Linjiang Road, Yuzhong District, Chongqing, 400010, China.

Department of Geriatrics, The Second Affiliated Hospital of Chongqing Medical University, No. 74, Linjiang Road, Yuzhong District, Chongqing, 400010, China.

出版信息

BMC Cardiovasc Disord. 2020 Sep 22;20(1):422. doi: 10.1186/s12872-020-01702-y.

DOI:10.1186/s12872-020-01702-y
PMID:32962654
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7507284/
Abstract

BACKGROUND

To determine whether intermittent hypoxia (IH) can reduce the infarct size (IS) after acute myocardial infarction (AMI) in rats.

METHODS

Articles were identified in PubMed, EMBASE and the Web of Science and were included if they evaluated the effect of IH on the changes in the infarcted area after AMI in rats.

RESULTS

A preliminary search identified 3633 articles and 29 data sets from 23 articles (12 in vivo, 16 in vitro). The IS decreased after AMI in IH rats both in vitro (SMD -1.46, 95% CI [- 2.37, - 0.55]; I = 85.6%, P = 0.000) and in vivo (SMD -1.43, 95% CI [- 2.05, - 0.82], I = 73.6%, P = 0.000). Sensitivity analysis indicated that IH had a strong protective effect against myocardial infarction, and the hypoxia concentration was significantly correlated with the change in IS after AMI.

CONCLUSION

IH can reduce IS after AMI in rats. This effect of IH may be related to the dose of hypoxia, and the oxygen concentration may be one of the most important influencing factors.

摘要

背景

为了确定间歇性低氧（IH）是否可以减少大鼠急性心肌梗死（AMI）后的梗死面积（IS）。

方法

在 PubMed、EMBASE 和 Web of Science 中检索文献，如果评估 IH 对 AMI 后大鼠梗死区变化的影响，则将其纳入研究。

结果

初步检索确定了 3633 篇文章和 23 篇文章中的 29 个数据集（12 个体内，16 个体外）。在体外（SMD -1.46，95%CI [-2.37，-0.55]；I=85.6%，P=0.000）和体内（SMD -1.43，95%CI [-2.05，-0.82]，I=73.6%，P=0.000），IH 组大鼠 AMI 后 IS 减少。敏感性分析表明 IH 对心肌梗死有很强的保护作用，缺氧浓度与 AMI 后 IS 的变化明显相关。

结论

IH 可减少大鼠 AMI 后的 IS。这种 IH 作用可能与缺氧剂量有关，氧浓度可能是最重要的影响因素之一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1e/7507284/b73f23f0afc1/12872_2020_1702_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1e/7507284/0fea43be6b76/12872_2020_1702_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1e/7507284/57ffb1277209/12872_2020_1702_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1e/7507284/aeb0f7617fec/12872_2020_1702_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1e/7507284/a7db5a209b8c/12872_2020_1702_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1e/7507284/46ae78006d51/12872_2020_1702_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1e/7507284/b73f23f0afc1/12872_2020_1702_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1e/7507284/0fea43be6b76/12872_2020_1702_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1e/7507284/57ffb1277209/12872_2020_1702_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1e/7507284/aeb0f7617fec/12872_2020_1702_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1e/7507284/a7db5a209b8c/12872_2020_1702_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1e/7507284/46ae78006d51/12872_2020_1702_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd1e/7507284/b73f23f0afc1/12872_2020_1702_Fig6_HTML.jpg

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