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病例报告:登革热病程中的多发性单神经炎。

Case report: Mononeuritis multiplex in the course of dengue fever.

机构信息

Seng Kang General Hospital, Singapore, Singapore.

出版信息

BMC Infect Dis. 2020 Sep 22;20(1):696. doi: 10.1186/s12879-020-05430-8.

Abstract

BACKGROUND

Dengue fever usually presents as a self-limiting acute febrile illness with worsening thrombocytopenia, with a small minority of patients developing hemorrhagic or life-threatening complications. Organ specific manifestations like myocarditis, acalculous cholecystitis, encephalitis has been described but are uncommon presentations. Even more rarely, such manifestations are the presenting complaint of Dengue fever. In this case report, we highlight a case of Dengue fever where unrelated neuropathies were the presenting complaint.

CASE PRESENTATION

An elderly man presents with 1 day of diplopia and left foot drop, associated with 2 days history of fever. A decreasing white cell count (WBC) and platelet on the 2nd day of admission prompted Dengue virus to be tested and a positive NS-1 antigen was detected, confirming the diagnosis of Dengue fever. He was treated with supportive treatment with a short duration of intravenous fluids recovered uneventfully and was discharged 6 days after admission with almost full resolution of diplopia and partial resolution of left foot drop. Left foot drop recovered completely 2 weeks later.

CONCLUSION

Neurological manifestations can be the presenting symptoms in Dengue fever, a diagnosis which should be borne in mind when such symptoms present in patients from endemic areas or in returning travellers from these areas.

摘要

背景

登革热通常表现为自限性急性发热疾病,伴有血小板减少症恶化,少数患者会出现出血或危及生命的并发症。已描述了心肌炎、无结石性胆囊炎、脑炎等特定器官表现,但这些表现并不常见。更罕见的是,这些表现是登革热的首发症状。在本病例报告中,我们强调了一例以无关性神经病为首发症状的登革热病例。

病例介绍

一名老年男性因复视和左脚下垂就诊,伴有发热 2 天。入院第 2 天白细胞计数(WBC)和血小板减少,促使检测登革病毒,检测到 NS-1 抗原阳性,确诊为登革热。他接受了支持性治疗,静脉补液时间短,恢复顺利,入院后 6 天出院,复视几乎完全缓解,左脚下垂部分缓解。左脚下垂在 2 周后完全恢复。

结论

在登革热患者中,神经表现可能是首发症状,当这些症状出现在来自流行地区的患者或从这些地区返回的旅行者中时,应考虑到这一诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b44/7509917/f9dc8f778ea5/12879_2020_5430_Fig1_HTML.jpg

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