Department of Neurology and Clinical Neurophysiology, University Hospital Augsburg, Augsburg, Germany.
Department of Neurology, University of Regensburg, Medbo Bezirksklinikum Regensburg, Regensburg, Germany.
Ultrasound Med Biol. 2020 Dec;46(12):3279-3285. doi: 10.1016/j.ultrasmedbio.2020.08.025. Epub 2020 Sep 19.
Optic nerve sheath diameter (ONSD) sonography is a reliable method for evaluation of intracranial pressure, yet there is a lack of reliable normal values. In the study described here, we established normal ONSD values in three different age groups and both sexes. One hundred eighty-seven volunteers without central nervous system disease were enrolled in this prospective study. ONSD measurements were taken in volunteers in the supine and upright positions and after application of positive end-expiratory pressure (PEEP). Normal ONSD values were 4.9-5.3 mm (patient age range: 20-85), with significant differences between men and women (p < 0.001). ONSD values increased with age (∆ = 0.34 mm, p < 0.001). There were no differences compared with the upright position but application of PEEP led to significantly increased ONSD values (∆ = 0.21 mm, p = 0.008). ONSD values increased with age, correlated well with the width of the third ventricle, were significantly lower in the female cohort and quickly responded to PEEP, especially in women.
视神经鞘直径（ONSD）超声检查是评估颅内压的可靠方法，但缺乏可靠的正常值。在本研究中，我们在三个不同年龄组和性别中建立了正常的 ONSD 值。187 名无中枢神经系统疾病的志愿者参与了这项前瞻性研究。志愿者在仰卧位和直立位以及应用呼气末正压（PEEP）时进行 ONSD 测量。正常的 ONSD 值为 4.9-5.3 毫米（患者年龄范围：20-85 岁），男女之间存在显著差异（p < 0.001）。ONSD 值随年龄增长而增加（∆ = 0.34 毫米，p < 0.001）。与直立位相比无差异，但应用 PEEP 会导致 ONSD 值显著增加（∆ = 0.21 毫米，p = 0.008）。ONSD 值随年龄增长而增加，与第三脑室宽度密切相关，女性队列的 ONSD 值明显较低，对 PEEP 反应迅速，尤其是在女性中。
