Ledda-Columbano G M, Columbano A, Coni P, Curto M, Faa G, Pani P
Toxicol Lett. 1987 Jun;37(1):85-90. doi: 10.1016/0378-4274(87)90171-8.
The effect of a single intragastric injection of 1,2-dibromoethane was investigated in kidneys of male Wistar rats. DNA synthesis as measured by the incorporation of tritiated thymidine was found to be approximately 5 times greater than that of controls 20-30 h after treatment. DNA synthesis was followed by a striking increase in the mitotic activity with a maximum at 30 h. The labeling and mitotic activities, after an initial increase, fell rapidly 48 h after treatment even though they were still higher than those of control animals. 1,2-Dibromoethane-induced cell proliferation is not a regenerative response because at the dose used in this study, no tubular necrosis was observed by histologic examination.
研究了单次胃内注射1,2 - 二溴乙烷对雄性Wistar大鼠肾脏的影响。通过氚标记胸腺嘧啶核苷掺入法测定的DNA合成，在处理后20 - 30小时发现比对照组大约高5倍。DNA合成之后有丝分裂活性显著增加，在30小时达到最大值。标记和有丝分裂活性在最初增加后，处理48小时后迅速下降，尽管仍高于对照动物。1,2 - 二溴乙烷诱导的细胞增殖不是一种再生反应，因为在本研究使用的剂量下，组织学检查未观察到肾小管坏死。
