Department of Radiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
Department of Ophthalmology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
Neural Plast. 2020 Sep 9;2020:8826787. doi: 10.1155/2020/8826787. eCollection 2020.
To explore altered regional neuronal activity in patients with nonarteritic anterior ischemic optic neuropathy (NAION) and its correlation with clinical performances using the regional homogeneity (ReHo) method, which is based on resting-state functional magnetic resonance imaging (fMRI).
Thirty-one patients with NAION (20 males, 11 females) and 31 age- and sex-matched normal controls (NCs) (20 males, 11 females) were enrolled in the study. All patients underwent ophthalmic examination, including eyesight, intraocular pressure measurement, optimal coherence tomography (OCT), visual field analysis, and fMRI scans. After ReHo was calculated, we investigated group differences in results between the patients and NCs. We analyzed the relationship between ReHo values for different brain regions in patients with NAION and intraocular pressure, visual field analysis, and OCT. A receiver operating characteristic (ROC) curve was used to assess the diagnostic ability of the ReHo method.
Compared with NCs, patients with NAION exhibited higher ReHo values in the left middle frontal gyrus, left middle cingulate gyrus, left superior temporal gyrus, and left inferior parietal lobule. Additionally, they exhibited lower ReHo values in the right lingual gyrus, left putamen/lentiform nucleus, and left superior parietal lobule. ReHo values in the left superior parietal lobule were negatively correlated with right retinal nerve fiber layer values ( = -0.462, = 0.01). The area under the ROC curve for each brain region indicated that the ReHo method is a credible means of diagnosing patient with NAION.
NAION was primarily associated with dysfunction in the default mode network, which may reflect its underlying neural mechanisms.
使用基于静息态功能磁共振成像（rs-fMRI）的局部一致性（ReHo）方法，探索非动脉炎性前部缺血性视神经病变（NAION）患者的局部神经元活动改变及其与临床表现的相关性。
本研究纳入了 31 例 NAION 患者（20 名男性，11 名女性）和 31 名年龄和性别匹配的正常对照组（NCs）（20 名男性，11 名女性）。所有患者均接受了眼科检查，包括视力、眼压测量、最佳相干断层扫描（OCT）、视野分析和 fMRI 扫描。计算 ReHo 后，我们研究了患者与 NCs 之间的结果组间差异。我们分析了 NAION 患者不同脑区的 ReHo 值与眼压、视野分析和 OCT 之间的关系。使用受试者工作特征（ROC）曲线评估 ReHo 方法的诊断能力。
与 NCs 相比，NAION 患者的左侧中央前回、左侧中央扣带回、左侧颞上回和左侧顶下小叶的 ReHo 值较高。此外，他们的右侧舌回、左侧壳核/苍白球和左侧顶叶上回的 ReHo 值较低。左侧顶叶上回的 ReHo 值与右眼视网膜神经纤维层值呈负相关（ = -0.462， = 0.01）。每个脑区的 ROC 曲线下面积表明 ReHo 方法是诊断 NAION 患者的可靠手段。
NAION 主要与默认模式网络功能障碍有关，这可能反映了其潜在的神经机制。
