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[药物制剂对前诱变化合物作用的修饰作用]

[Modifying action of drug preparations on the effect of promutagen compounds].

作者信息

Oblapenko N G, Fonshteĭn L M

出版信息

Tsitol Genet. 1987 Mar-Apr;21(2):118-22.

PMID:3296365
Abstract

The Ames test has shown that the action of nitrosomorpholine and cyclophosphane promutagens on bacteria of Salmonella typhimurium TA 1950 increases while using S-9 liver fraction of rats treated with pharmaceuticals of amidopyrine, reserpine and pyrazidol and decreases while using those treated with phenazepam.

摘要

艾姆斯试验表明,在使用经氨基比林、利血平和吡唑醇药物处理的大鼠肝脏S-9组分时,亚硝基吗啉和环磷酰胺前诱变剂对鼠伤寒沙门氏菌TA 1950细菌的作用增强;而在使用经苯氮䓬处理的大鼠肝脏S-9组分时,其作用减弱。

相似文献

1
[Modifying action of drug preparations on the effect of promutagen compounds].[药物制剂对前诱变化合物作用的修饰作用]
Tsitol Genet. 1987 Mar-Apr;21(2):118-22.
2
[Study of promutagen biotransformation in the Ames test. III. The role of conjugation with glucuronic acid and sulfate in the modification of mutagenic effect of nitrosomorpholine, diethylnitrosamine and cyclophosphamide].艾姆斯试验中前诱变剂生物转化的研究。III. 与葡萄糖醛酸和硫酸盐结合在亚硝基吗啉、二乙基亚硝胺和环磷酰胺诱变作用修饰中的作用
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3
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4
[Study of the biotransformation of various antineoplastic agents using the Ames test].
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5
[The process of promutagen biotransformation studied by the Ames test. II. The extent of the manifestation of the mutagenic action of nitrosomorpholine, diethylnitrosamine and cyclophosphane using various subfractions of rat liver homogenate].[通过艾姆斯试验研究前诱变剂生物转化过程。II. 使用大鼠肝脏匀浆的各种亚组分对亚硝基吗啉、二乙基亚硝胺和环磷酰胺诱变作用的表现程度]
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[Study of promutagen biotransformation in the Ames test. IV. The effect of transplanted tumors on the biotransformation of various antineoplastic agents].[艾姆斯试验中前诱变剂生物转化的研究。IV. 移植肿瘤对各种抗肿瘤药物生物转化的影响]
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[The role of UDP glucuronosyl- and sulfotransferases in the butylhydroxytoluene suppression of the mutagenic action of carcinogenic nitroso compounds and cyclophosphane].[尿苷二磷酸葡萄糖醛酸基转移酶和磺基转移酶在丁基羟基甲苯抑制致癌亚硝基化合物和环磷酰胺诱变作用中的作用]
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Biull Eksp Biol Med. 1984 Aug;98(8):196-8.
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[Butylhydroxytoluene inhibition of the mutagenic activity of carcinogenic nitroso compounds and cyclophosphamide: the role of the glutathione conjugation reaction].
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