Takeo Toru, Nakao Satohiro, Nakagawa Yoshiko, Sztein Jorge M, Nakagata Naomi
Division of Reproductive Engineering, Center for Animal Resources and Development, Institute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Kumamoto, 860-0811 Japan.
Division of Reproductive Biotechnology and Innovation, Center for Animal Resources and Development, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan.
Lab Anim Res. 2020 Sep 17;36:33. doi: 10.1186/s42826-020-00066-w. eCollection 2020.
The cryopreservation of sperm and embryos is useful to efficiently archive valuable resources of genetically engineered mice. Till date, more than 60,000 strains of genetically engineered mice have been archived in mouse banks worldwide. Researchers can request for the archived mouse strains for their research projects. The research infrastructure of mouse banks improves the availability of mouse resources, the productivity of research projects, and the reproducibility of animal experiments. Our research team manages the mouse bank at the Center for Animal Resources and Development in Kumamoto University and continuously develops new techniques in mouse reproductive technology to efficiently improve the system of mouse banking. In this review, we introduce the activities of mouse banks and the latest techniques used in mouse reproductive technology.
精子和胚胎的冷冻保存有助于高效存档基因工程小鼠的宝贵资源。迄今为止，全球小鼠库中已存档超过60000种基因工程小鼠品系。研究人员可以为其研究项目申请存档的小鼠品系。小鼠库的研究基础设施提高了小鼠资源的可用性、研究项目的生产力以及动物实验的可重复性。我们的研究团队管理着熊本大学动物资源与开发中心的小鼠库，并不断开发小鼠生殖技术的新技术，以有效改进小鼠库系统。在这篇综述中，我们介绍了小鼠库的活动以及小鼠生殖技术中使用的最新技术。
