帕博利珠单抗成功治疗转移性难治性妊娠滋养细胞肿瘤：滋养细胞肿瘤免疫检查点挽救治疗的一个病例
Successful treatment of metastatic refractory gestational choriocarcinoma with pembrolizumab: A case for immune checkpoint salvage therapy in trophoblastic tumors.
作者信息
Clair Kiran H, Gallegos Nicolas, Bristow Robert E
机构信息
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of California Irvine Medical Center, Orange, CA, United States.
Department of Pathology, University of California Irvine Medical Center, Orange, CA, United States.
出版信息
Gynecol Oncol Rep. 2020 Sep 1;34:100625. doi: 10.1016/j.gore.2020.100625. eCollection 2020 Nov.
•Cure rates are high for choriocarcinoma, however chemoresistant disease often leads to death.•High expression of PD-L1 suggests a role for checkpoint inhibitors in choriocarcinoma.•Pembrolizumab should be considered for salvage therapy for chemoresistant choriocarcinoma.
•绒毛膜癌的治愈率很高，然而化疗耐药性疾病常常导致死亡。
•程序性死亡受体1配体（PD-L1）的高表达表明检查点抑制剂在绒毛膜癌中发挥作用。
•对于化疗耐药性绒毛膜癌的挽救治疗，应考虑使用帕博利珠单抗。
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