Centro de Investigación en Alimentación y Desarrollo, A.C. Coordinación Culiacán, Carretera a Eldorado Km 5.5 Col. Campo El Diez, CP 80110, Culiacán, Sinaloa, Mexico.
Cátedras CONACYT-Centro de Investigación en Alimentación y Desarrollo, A.C. Coordinación Culiacán, Carretera a Eldorado Km 5.5 Col. Campo El Diez, CP 80110, Culiacán, Sinaloa, Mexico.
Plant Foods Hum Nutr. 2020 Dec;75(4):467-476. doi: 10.1007/s11130-020-00856-6. Epub 2020 Sep 22.
Colorectal cancer (CRC) is the second most deadly and the third most commonly diagnosed cancer in the world. CRC treatment is mainly based on surgery, chemotherapy, and even though the probability of complications after surgery is very low, chemo drugs affect the patient's quality of life. Multiple studies have shown a strong correlation between diet and the onset and progression of CRC. Thus, the consumption of dietary nutraceuticals for its treatment and prevention has been suggested as a promising option. Peptides have increasingly become of interest in human health due to their antioxidant, antihypertensive, and anticancer potential. In recent years, there have been extensive reports on peptides with anti-tumor activity, and some studies suggest that peptides modulate cell proliferation, evasion of cell death, and metastasis in malignant cells. Plant-derived peptides such as soybean, bean, and rice have received main attention. In this review, we show evidence of several mechanisms through which bioactive peptides exert anti-tumor activity over in vitro and in vivo CRC models. We also report the current status of major production techniques, as well as limitations and future perspectives. Graphical Abstract.
结直肠癌（CRC）是全球第二大致命性和第三大常见癌症。CRC 的治疗主要基于手术、化疗，尽管手术后并发症的概率非常低，但化疗药物会影响患者的生活质量。多项研究表明，饮食与 CRC 的发病和进展之间存在很强的相关性。因此，人们提出了将膳食营养保健品用于治疗和预防 CRC 的方法。由于其具有抗氧化、降血压和抗癌潜力，肽类在人类健康方面越来越受到关注。近年来，关于具有抗肿瘤活性的肽类的报道很多，一些研究表明，肽类可以调节恶性细胞的增殖、逃避细胞死亡和转移。植物来源的肽类，如大豆、豆类和大米，受到了主要关注。在本综述中，我们展示了生物活性肽通过体外和体内 CRC 模型发挥抗肿瘤活性的几种机制的证据。我们还报告了主要生产技术的现状，以及存在的局限性和未来展望。
