National Center for Biotechnology, Nur-Sultan, Kazakhstan.
National Scientific Center for Phthisiopulmonology, Almaty, Kazakhstan.
Mem Inst Oswaldo Cruz. 2020 Sep 18;115:e200215. doi: 10.1590/0074-02760200215. eCollection 2020.
The human-adapted strains of the Mycobacterium tuberculosis complex (MTBC) comprise seven phylogenetic lineages originally associated with their geographical distribution. Here, we report the genomes of three drug-resistant clinical isolates of the Latin American-Mediterranean (LAM) family collected in Kazakhstan. We utilised whole-genome sequencing to study the distribution and drug resistance of these isolates. Phylogenetic analysis grouped the genomes described in this study with the sequences from Russia, Uzbekistan, and Kazakhstan belonging to the LAM family. One isolate has acquired extensive drug resistance to seven antituberculosis drugs. Our results suggest at least two multi-drug resistant (MDR)/extensively drug-resistant (XDR)-associated genotypes of the LAM family circulate in Kazakhstan.
人类适应的结核分枝杆菌复合群（MTBC）菌株包括最初与其地理分布相关的七个系统发育谱系。在这里，我们报告了在哈萨克斯坦收集的三种抗药性临床分离株的基因组，这些分离株属于拉丁美洲-地中海（LAM）家族。我们利用全基因组测序来研究这些分离株的分布和耐药性。系统发育分析将本研究中描述的基因组与来自俄罗斯、乌兹别克斯坦和哈萨克斯坦的 LAM 家族序列进行了分组。一个分离株对七种抗结核药物产生了广泛的耐药性。我们的结果表明，哈萨克斯坦至少存在两种流行的 LAM 家族的耐多药/广泛耐药（MDR/XDR）相关基因型。
