结核分枝杆菌4型包括全球分布和地理上受限的亚分支。
Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.
作者信息
Stucki David, Brites Daniela, Jeljeli Leïla, Coscolla Mireia, Liu Qingyun, Trauner Andrej, Fenner Lukas, Rutaihwa Liliana, Borrell Sonia, Luo Tao, Gao Qian, Kato-Maeda Midori, Ballif Marie, Egger Matthias, Macedo Rita, Mardassi Helmi, Moreno Milagros, Tudo Vilanova Griselda, Fyfe Janet, Globan Maria, Thomas Jackson, Jamieson Frances, Guthrie Jennifer L, Asante-Poku Adwoa, Yeboah-Manu Dorothy, Wampande Eddie, Ssengooba Willy, Joloba Moses, Henry Boom W, Basu Indira, Bower James, Saraiva Margarida, Vaconcellos Sidra E G, Suffys Philip, Koch Anastasia, Wilkinson Robert, Gail-Bekker Linda, Malla Bijaya, Ley Serej D, Beck Hans-Peter, de Jong Bouke C, Toit Kadri, Sanchez-Padilla Elisabeth, Bonnet Maryline, Gil-Brusola Ana, Frank Matthias, Penlap Beng Veronique N, Eisenach Kathleen, Alani Issam, Wangui Ndung'u Perpetual, Revathi Gunturu, Gehre Florian, Akter Suriya, Ntoumi Francine, Stewart-Isherwood Lynsey, Ntinginya Nyanda E, Rachow Andrea, Hoelscher Michael, Cirillo Daniela Maria, Skenders Girts, Hoffner Sven, Bakonyte Daiva, Stakenas Petras, Diel Roland, Crudu Valeriu, Moldovan Olga, Al-Hajoj Sahal, Otero Larissa, Barletta Francesca, Jane Carter E, Diero Lameck, Supply Philip, Comas Iñaki, Niemann Stefan, Gagneux Sebastien
机构信息
Swiss Tropical and Public Health Institute, Basel, Switzerland.
University of Basel, Switzerland.
出版信息
Nat Genet. 2016 Dec;48(12):1535-1543. doi: 10.1038/ng.3704. Epub 2016 Oct 31.
Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.
泛化种和特化种在其生态位宽度上存在差异。对于专性人类病原体的生态位宽度，我们知之甚少。在此，我们分析了结核分枝杆菌4型临床分离株的全球样本集，这是人类结核病在地理上分布最广的病因。我们发现4型包含全球分布和地理受限的亚分支，这表明泛化种和特化种之间存在区别。群体基因组分析表明，虽然大多数人类T细胞表位在所有亚分支中都是保守的，但可变表位的比例在泛化种中更高。我们的数据进一步支持最常见的泛化种亚分支起源于欧洲。因此，4型的全球成功反映了不同亚分支所采用的不同策略以及人类迁移的影响。
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