Department of Endodontics, Case School of Dental Medicine, 2123 Abington Road, A 280, Cleveland, OH, 44106, USA.
Department of Endodontics, UMKC School of Dentistry, Kansas City, MO, USA.
Clin Oral Investig. 2020 Nov;24(11):3813-3819. doi: 10.1007/s00784-020-03596-8. Epub 2020 Sep 23.
To date, the relationship between cardiovascular disease (CVD) and endodontic treatment outcomes remains elusive with mixed reports. Thus, the purpose of this systematic review of longitudinal cohort studies was to evaluate whether CVD was a risk factor for endodontic outcome.
Two reviewers independently conducted a comprehensive electronic database search to July 2020. The bibliographies of all relevant articles, textbooks, and gray literature were manually searched. The methodological quality of evidence was appraised by the Newcastle-Ottawa Scale and GRADE. The authors considered any publication on CVD and endodontic outcome. Endodontic outcome referred to either healing or survival of endodontically treated tooth. Risk ratio (RR) with 95% confidence interval (CI) was used.
Three articles met the inclusion criteria with a low risk of bias. Patients with CVD demonstrated a 67% higher risk for negative endodontic outcomes compared with patients who were healthy (RR = 1.67, P = 0.001, 95% confidence interval 1.53-1.81).
With the limitations of this systematic review, the overall confidence by GRADE was moderate suggesting that CVD might be a risk factor for endodontic outcomes.
The results support an association between CVD and endodontic outcomes.
迄今为止，心血管疾病（CVD）与牙髓治疗结果之间的关系仍难以捉摸，报告结果不一。因此，本系统评价的目的是评估 CVD 是否是牙髓治疗结果的危险因素。
两名审查员独立进行了全面的电子数据库搜索，截止到 2020 年 7 月。所有相关文章、教科书和灰色文献的书目均进行了手动搜索。使用纽卡斯尔-渥太华量表和 GRADE 评估证据的方法学质量。作者考虑了任何关于 CVD 和牙髓治疗结果的出版物。牙髓治疗结果是指牙髓治疗的牙齿的愈合或存活。使用风险比（RR）和 95%置信区间（CI）。
有 3 篇文章符合纳入标准，偏倚风险较低。与健康患者相比，CVD 患者的负面牙髓治疗结果风险高 67%（RR = 1.67，P = 0.001，95%置信区间 1.53-1.81）。
鉴于本系统评价的局限性，GRADE 的总体置信度为中度，表明 CVD 可能是牙髓治疗结果的一个危险因素。
这些结果支持 CVD 与牙髓治疗结果之间的关联。
