Ahmadzada Sejad, Vasan Kartik, Sritharan Niranjan, Singh Narinder, Smith Mark, Hull Isabelle, Riffat Faruque
Department of Otolaryngology - Head and Neck Surgery, Westmead Hospital, Westmead, New South Wales, Australia.
The University of Sydney, Sydney, Australia.
Head Neck. 2020 Nov;42(11):3427-3437. doi: 10.1002/hed.26428. Epub 2020 Sep 23.
This systematic review and meta-analysis evaluates the validity of narrowband imaging (NBI) in differentiating between low-risk leukoplakia and high-risk leukoplakia. Medline, EMBASE, Scopus, Cochrane Database of Systematic Reviews and Database of Abstracts of Reviews of Effects were searched. Studies evaluating the diagnostic accuracy of NBI in the assessment of laryngeal leukoplakia were included. Pooled sensitivity, specificity and diagnostic odds ratio were calculated. Seven studies met the inclusion criteria assessing a total of 586 lesions with laryngeal leukoplakia. In differentiating between low-risk and high-risk leukoplakia, NBI had a pooled sensitivity and specificity of 85.4% (95% CI [76-99.9]) and 94.9% (95% CI [91.1-97.2]) respectively. Pooled diagnostic odds ratio was 99.2 (95% CI [38.28-257.18]). NBI is a useful imaging modality in differentiating between low-risk leukoplakia and high-risk laryngeal leukoplakia. The high sensitivity, specificity and diagnostic odds ratio make NBI a useful tool in the workup of laryngeal leukoplakia.
本系统评价和荟萃分析评估了窄带成像（NBI）在鉴别低风险白斑和高风险白斑方面的有效性。检索了Medline、EMBASE、Scopus、Cochrane系统评价数据库和循证医学数据库。纳入了评估NBI在喉白斑评估中诊断准确性的研究。计算了合并敏感性、特异性和诊断比值比。七项研究符合纳入标准，共评估了586例喉白斑病变。在鉴别低风险和高风险白斑时，NBI的合并敏感性和特异性分别为85.4%（95%CI[76-99.9]）和94.9%（95%CI[91.1-97.2]）。合并诊断比值比为99.2（95%CI[38.28-257.18]）。NBI是鉴别低风险白斑和高风险喉白斑的一种有用的成像方式。高敏感性、特异性和诊断比值比使NBI成为喉白斑检查的一种有用工具。
