Wang Qi, Ling Yi, Huang Yang-Yi-Yi, Li Lin-Rong, Shen Lei, Zhang Jian, Fan Guo-Kang
Department of Otolaryngology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Jie Fang Road 88, Hangzhou, 310000, Zhejiang, China.
Eur Arch Otorhinolaryngol. 2024 Mar;281(3):1409-1416. doi: 10.1007/s00405-023-08390-2. Epub 2023 Dec 26.
This study evaluated vocal fold leukoplakia using i-scan combined with laryngovideostroboscopy for risk assessment prediction.
A total of 141 patients with 218 lesions were enrolled in this study. Morphological characteristics of leukoplakia, assessment of the vascular pattern using i-scan, and vocal fold vibratory function were analyzed.
The number of patients with no, mild, moderate, severe dysplasia, and invasive carcinoma were 68, 40, 17, 46 and 47, respectively. The sensitivity of morphological characteristic, vascular pattern, vibratory function and predictive model were 77.4%, 72%, 69.9%, and 82.8%, respectively. Receiver operating characteristic curve analysis of morphological characteristic, vascular pattern, vibratory function and predictive model were 0.771, 0.824, 0.769, and 0.923, respectively. The results of logistic regression analysis showed that rough morphological types, perpendicular vascular pattern, severe decrease and absence of mucosal waves increased the risk of malignancy (OR = 5.531, 4.973, and 16.992, respectively; P < 0.001).
I-scan combined with laryngovideostroboscopy can improve the differential diagnosis of low-risk and high-risk vocal fold leukoplakia.
本研究使用i-scan联合喉动态镜检查评估声带白斑的风险评估预测。
本研究共纳入141例患者的218个病变。分析了白斑的形态学特征、使用i-scan评估血管形态以及声带振动功能。
无发育异常、轻度发育异常、中度发育异常、重度发育异常和浸润性癌的患者数量分别为68、40、17、46和47例。形态学特征、血管形态、振动功能和预测模型的敏感性分别为77.4%、72%、69.9%和82.8%。形态学特征、血管形态、振动功能和预测模型的受试者工作特征曲线分析分别为0.771、0.824、0.769和0.923。逻辑回归分析结果显示，粗糙的形态类型、垂直的血管形态、黏膜波严重减弱和消失增加了恶性风险（OR分别为5.531、4.973和16.992；P<0.001）。
i-scan联合喉动态镜检查可改善低风险和高风险声带白斑的鉴别诊断。
