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原发性开角型青光眼临床及分子标志物的计算分析与新的诊疗可能性

Computational Analysis of Clinical and Molecular Markers and New Theranostic Possibilities in Primary Open-Angle Glaucoma.

作者信息

Pinazo-Durán María D, García-Medina José J, Bolarín José M, Sanz-González Silvia M, Valero-Vello Mar, Abellán-Abenza Javier, Zanón-Moreno Vicente, Moreno-Montañés Javier

机构信息

Ophthalmic Research Unit "Santiago Grisolía"/FISABIO and Cellular and Molecular Ophthalmo-Biology Group of the University of Valencia, 46010 Valencia, Spain.

Researchers of the Spanish Net of Ophthalmic Research "OFTARED" RD16/0008/0022, of the Institute of Health Carlos III, 28029 Madrid, Spain.

出版信息

J Clin Med. 2020 Sep 21;9(9):3032. doi: 10.3390/jcm9093032.

DOI:10.3390/jcm9093032
PMID:32967086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7564865/
Abstract

Primary open-angle glaucoma (POAG) is a paramount cause of irreversible visual disability worldwide. We focus on identifying clinical and molecular facts that may help elucidating the pathogenic mechanisms of the disease. By using ophthalmological approaches (biomicroscopy, ocular fundus, optical coherence tomography, and perimetry) and experimental tests (enzyme-linked immunosorbent assay (ELISA), high performance liquid chromatography (HPLC), and Western blot/immunoblotting) directed to evaluate the oxidative stress, inflammation, apoptosis, and neurodegeneration processes, we gather information to build a network of data to perform a computational bioinformatics analysis. Our results showed strong interaction of the above players and its downstream effectors in POAG pathogenesis. In conclusion, specific risk factors were identified, and molecules involved in multiple pathways were found in relation to anterior and posterior eye segment glaucoma changes, pointing to new theranostic challenges for better managing POAG progression.

摘要

原发性开角型青光眼（POAG）是全球不可逆视力残疾的首要原因。我们专注于识别可能有助于阐明该疾病致病机制的临床和分子事实。通过使用眼科方法（生物显微镜检查、眼底检查、光学相干断层扫描和视野检查）以及旨在评估氧化应激、炎症、细胞凋亡和神经退行性变过程的实验测试（酶联免疫吸附测定（ELISA）、高效液相色谱（HPLC）和蛋白质免疫印迹法），我们收集信息以构建一个数据网络，从而进行计算生物信息学分析。我们的结果表明，上述因素及其下游效应器在POAG发病机制中存在强烈相互作用。总之，我们确定了特定的风险因素，并且发现了与眼前段和眼后段青光眼变化相关的涉及多种途径的分子，这为更好地管理POAG进展带来了新的治疗诊断挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53bf/7564865/51d937243999/jcm-09-03032-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53bf/7564865/e35efec91850/jcm-09-03032-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53bf/7564865/c97329663769/jcm-09-03032-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53bf/7564865/fe64fc213d16/jcm-09-03032-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53bf/7564865/224357b4d199/jcm-09-03032-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53bf/7564865/6189f75152f6/jcm-09-03032-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53bf/7564865/90d0e405fd0f/jcm-09-03032-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53bf/7564865/51d937243999/jcm-09-03032-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53bf/7564865/e35efec91850/jcm-09-03032-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53bf/7564865/c97329663769/jcm-09-03032-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53bf/7564865/fe64fc213d16/jcm-09-03032-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53bf/7564865/224357b4d199/jcm-09-03032-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53bf/7564865/6189f75152f6/jcm-09-03032-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53bf/7564865/90d0e405fd0f/jcm-09-03032-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53bf/7564865/51d937243999/jcm-09-03032-g007.jpg

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