McNamee J E
J Appl Physiol Respir Environ Exerc Physiol. 1983 Apr;54(4):914-8. doi: 10.1152/jappl.1983.54.4.914.
Histamine increases lymph flow and protein flux from the sheep lung. This increase in water and protein movement has been attributed to an increase in lung microvascular permeability-surface area product caused by histamine. Whether it was permeability that was changed or whether it was surface area cannot be discerned from past work. Histamine might increase either of these determinants of transport in the sheep lung. Previous measurements of several plasma protein fractions in plasma and lymph showed no change in the sieving behavior of the microcirculation with intravenous histamine, suggesting that only surface area was changed. In the present study, even larger test molecules were used to probe the limits of transport through the lung's blood-lymph barrier. Fluorescein isothiocyanate-labeled dextrans (FITC-dextran) that can normally permeate lung lymph do so more readily after intravenous histamine infusion (3 micrograms X kg-1 X min-1). Formerly impermeable FITC-dextran fractions also appear after histamine administration. No definitive size limit to the transport of dextran was found in histamine-stimulated sheep lungs. Intra-arterial histamine does not increase lung lymph, protein, or FITC-dextran flow. These results suggest that histamine changes the permeability or sieving characteristics of the lung microvascular barrier making it less size selective to large molecules. Surface area for transport may also increase.
组胺可增加绵羊肺的淋巴液流量和蛋白质通量。水和蛋白质流动的这种增加归因于组胺引起的肺微血管通透性 - 表面积乘积的增加。过去的研究无法确定是通透性发生了变化还是表面积发生了变化。组胺可能增加了绵羊肺中这两个转运决定因素中的任何一个。先前对血浆和淋巴液中几种血浆蛋白组分的测量表明，静脉注射组胺后微循环的筛分行为没有变化，这表明只有表面积发生了变化。在本研究中，使用了更大的测试分子来探究通过肺血 - 淋巴屏障的转运极限。静脉注射组胺（3微克·千克⁻¹·分钟⁻¹）后，通常可透过肺淋巴液的异硫氰酸荧光素标记葡聚糖（FITC - 葡聚糖）更容易透过。组胺给药后，以前不能透过的FITC - 葡聚糖组分也出现了。在组胺刺激的绵羊肺中未发现葡聚糖转运的明确大小限制。动脉内注射组胺不会增加肺淋巴液、蛋白质或FITC - 葡聚糖的流量。这些结果表明，组胺改变了肺微血管屏障的通透性或筛分特性，使其对大分子的大小选择性降低。转运表面积也可能增加。
