中性粒细胞与淋巴细胞比值作为轻度创伤性脑损伤中计算机断层扫描应用的预测生物标志物。
Neutrophil to lymphocyte ratio as a predictive biomarker for computed tomography scan use in mild traumatic brain injury.
作者信息
Alexiou George A, Lianos Georgios D, Tzima Aggeliki, Sotiropoulos Athanasios, Nasios Anastasios, Metaxas Dimitris, Zigouris Andreas, Rn Jolanda Zika, Mitsis Michail, Voulgaris Spyridon
机构信息
Department of Neurosurgery, University Hospital of Ioannina, Ioannina, Greece.
Department of Surgery, University Hospital of Ioannina, Ioannina, Greece.
出版信息
Biomark Med. 2020 Aug;14(12):1085-1090. doi: 10.2217/bmm-2020-0150.
Traumatic brain injury (TBI) is a serious health concern. We set out to investigate the role of neutrophil-to-lymphocytes ratio (NLR) at admission for predicting the need for computed tomography (CT) in mild-TBI. A retrospective study of adult patients who presented with mild-TBI One hundred and thirty patients met the inclusion criteria. Seventy-four patients had positive CT-findings. The mean NLR-levels at presentations were 5.6 ± 4.8. Patients with positive CT-findings had significant higher NLR-levels. Receiver operating characteristic curve analysis was conducted and the threshold of NLR-levels for detecting the cases with positive CT-findings was 2.5, with 78.1% sensitivity and 63% specificity To the best of our knowledge no previous study has assessed the value of NLR-levels for predicting the need for CT in mild-TBI.
创伤性脑损伤（TBI）是一个严重的健康问题。我们着手研究入院时中性粒细胞与淋巴细胞比值（NLR）在预测轻度创伤性脑损伤患者是否需要进行计算机断层扫描（CT）方面的作用。对成年轻度创伤性脑损伤患者进行了一项回顾性研究。130例患者符合纳入标准。74例患者CT检查结果为阳性。就诊时的平均NLR水平为5.6±4.8。CT检查结果为阳性的患者NLR水平显著更高。进行了受试者工作特征曲线分析，检测CT检查结果为阳性病例的NLR水平阈值为2.5，敏感性为78.1%，特异性为63%。据我们所知，以前没有研究评估过NLR水平在预测轻度创伤性脑损伤患者是否需要CT方面的价值。
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