Kawadler Jamie M, Hemmings Nicola Rose, Ponzo Sonia, Morelli Davide, Bird Geoffrey, Plans David
Huma Therapeutics Limited, 13th Floor Millbank Tower, 21-24 Millbank, London, United Kingdom.
Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom.
JMIR Form Res. 2020 Nov 10;4(11):e18067. doi: 10.2196/18067.
The prevalence of workplace-related stress and anxiety is high, resulting in stress-related physical and mental illness. Digital self-guided interventions aimed at key areas of workplace design may be able to provide remote anxiolytic effects.
The aim of this feasibility study is to assess changes in anxiety and mental well-being after use of the BioBase programme, a mobile phone platform for psycho-educational modules, tools, and real-time feedback of physiological data.
A 4-week observational study was carried out in 55 healthy adults who were screened for stress with the Depression Anxiety Stress Scale (DASS) Stress subscale. Participants completed anxiety (6-item State-Trait Anxiety Inventory [STAI]) and mental well-being (Warwick-Edinburgh Mental Well-being Scale [WEMWBS]) questionnaires at baseline and at 4 weeks. Feedback questionnaires were administered after 4 weeks.
After 4 weeks of using the programme and controlling for any effect of being paid to take part in the study, STAI significantly decreased (baseline mean 45.52 [SD 13.2]; 4-week mean 39.82 [SD 11.2]; t=-3.51; P<.001; CI -8.88 to -2.52; Cohen d=0.96) and WEMWBS significantly increased (baseline mean 48.12 [SD 6.4]; 4-week mean 50.4 [SD 6.9]; t=2.41; P=.019; CI 0.44-4.23; Cohen d=0.66). Further, higher baseline stress was significantly associated with a greater decrease in STAI (t=-3.41; P=.001; CI -8.10 to -2.10; R=0.180) and a greater increase in WEMWBS (t=2.41; P=.019; CI 0.38-4.11, R=0.101). On feedback, participants found the programme easy to use/navigate, with the content being acceptable and relevant to workplace-related stressors; 70% (21/30) of participants would recommend the programme to a friend.
The BioBase programme is a potentially effective intervention in decreasing anxiety and increasing mental well-being, with larger changes in those with higher baseline levels of stress.
与工作场所相关的压力和焦虑患病率很高，会导致与压力相关的身心疾病。针对工作场所设计关键领域的数字自助干预措施或许能够提供远程抗焦虑效果。
本可行性研究的目的是评估使用BioBase程序后焦虑和心理健康状况的变化，该程序是一个用于心理教育模块、工具和生理数据实时反馈的手机平台。
对55名健康成年人进行了为期4周的观察性研究，这些成年人用抑郁焦虑压力量表（DASS）压力分量表进行了压力筛查。参与者在基线时和4周时完成了焦虑（6项状态-特质焦虑量表[STAI]）和心理健康（沃里克-爱丁堡心理健康量表[WEMWBS]）问卷。4周后进行反馈问卷调查。
在使用该程序4周并控制参与研究获得报酬的任何影响后，STAI显著降低（基线均值45.52[标准差13.2]；4周均值39.82[标准差11.2]；t=-3.51；P<.001；置信区间-8.88至-2.52；科恩d=0.96），WEMWBS显著增加（基线均值48.12[标准差6.4]；4周均值50.4[标准差6.9]；t=2.41；P=.019；置信区间0.44 - 4.23；科恩d=0.66）。此外，更高的基线压力与STAI的更大降低（t=-3.41；P=.001；置信区间-8.10至-2.10；R=0.180）和WEMWBS的更大增加（t=2.41；P=.019；置信区间0.38 - 4.11，R=0.101）显著相关。在反馈中，参与者发现该程序易于使用/操作，内容可接受且与工作场所相关压力源相关；70%（21/30）的参与者会向朋友推荐该程序。
BioBase程序是一种在降低焦虑和提高心理健康方面可能有效的干预措施，基线压力水平较高者的变化更大。
