Department of Medical Microbiology, School of Basic Medical Sciences, Central South University, Changsha, China.
Department of Clinical Laboratory, Hunan Cancer Hospital, the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
J Drug Target. 2021 Mar;29(3):249-258. doi: 10.1080/1061186X.2020.1824235. Epub 2020 Oct 7.
is a gram-negative bacterium that exists in various ecosystems, causing severe infections in patients with AIDS or cystic fibrosis. can form biofilm on a variety of surfaces, whereby the bacteria produce defensive substances and enhance antibiotic-resistance, making themselves more adaptable to hostile environments. resistance represents one of the main causes of infection-related morbidity and mortality at a global level. Iron is required for the growth of biofilm. This review summarises how the iron metabolism contributes to develop biofilm, and more importantly, it may provide some references for the clinic to achieve novel anti-biofilm therapeutics by targeting iron activities.
是一种革兰氏阴性菌，存在于各种生态系统中，可导致艾滋病或囊性纤维化患者发生严重感染。 可在各种表面形成生物膜，使细菌产生防御物质并增强抗生素耐药性，从而使其更能适应恶劣环境。 耐药性是全球范围内导致感染相关发病率和死亡率的主要原因之一。铁是 生物膜生长所必需的。本文综述了铁代谢如何促进生物膜的形成，更重要的是，它可能为临床通过靶向铁活性来实现新型抗生物膜治疗提供一些参考。
