Fuh M M, Shieh S M, Wu D A, Chen Y D, Reaven G M
Arch Intern Med. 1987 Jun;147(6):1035-8.
Plasma glucose, insulin, and lipoprotein concentrations were determined in 20 men with hypertension, and compared with values in 20 normotensive men of comparable age and body mass index. The results demonstrated a significant increase in both the plasma glucose and insulin response to a 75-g oral glucose challenge (two-way analysis of variance). In addition, a significant correlation existed between the plasma blood pressure. Finally, the greater the plasma glucose insulin response to oral glucose and both systolic and diastolic and insulin responses to oral glucose, the lower the plasma high-density lipoprotein concentrations, and the higher the ratio of plasma low-density lipoprotein cholesterol to high-density lipoprotein cholesterol. Thus, abnormalities of plasma glucose, insulin, and lipoprotein metabolism exist in patients with untreated hypertension, and these changes may contribute to the increased risk for coronary artery disease associated with hypertension.
对20名高血压男性的血浆葡萄糖、胰岛素和脂蛋白浓度进行了测定，并与20名年龄和体重指数相当的血压正常男性的值进行了比较。结果显示，在75克口服葡萄糖激发试验中，血浆葡萄糖和胰岛素反应均显著增加（双向方差分析）。此外，血浆血压之间存在显著相关性。最后，口服葡萄糖后血浆葡萄糖胰岛素反应以及收缩压和舒张压及胰岛素反应越大，血浆高密度脂蛋白浓度越低，血浆低密度脂蛋白胆固醇与高密度脂蛋白胆固醇的比值越高。因此，未经治疗的高血压患者存在血浆葡萄糖、胰岛素和脂蛋白代谢异常，这些变化可能导致与高血压相关的冠状动脉疾病风险增加。
