Bursztyn M, Raz I
Department of Medicine, Hadassah University Hospital, Jersalem, Israel.
J Hypertens. 1995 Jan;13(1):57-61.
Hyperinsulinaemia may be associated with hypertension, hyperlipidaemia and glucose intolerance. In the present study we compared the consequence of immigration from Ethiopia to Israel in order to elucidate environmental effects on these variables.
A cross-sectional analysis of 337 young, male Ethiopian immigrants who were placed in boarding schools were divided into two groups: group I was in Israel for < 3 months (n = 180) and group II was in Israel for > 2 years (n = 157). Both groups were attending the same schools and were fed from the same kitchens.
Sitting blood pressure, body mass index, triceps skinfold width, fasting lipids insulin and glucose levels were measured and a standard (75-g) oral glucose-tolerance test was performed.
Both groups had similar body mass index. Group I was younger than group II. Both systolic and diastolic blood pressure were significantly higher in group II than in group I. Hypertension was more prevalent in group II. Impaired glucose tolerance (from the oral glucose-tolerance test) prevalence did not differ between the groups, neither did the glycosylated haemoglobin nor fructosamine level. The insulinogenic index (ratio of the areas under the curve of the insulin to that of the glucose level during the oral glucose-tolerance test) was significantly higher in group II. Total and high-density lipoprotein-cholesterol levels were significantly higher in group II. In stepped multiple regression analysis, belonging to group II and having higher insulinogenic index predicted hypertension.
This cross-sectional comparison of young, very lean Ethiopian immigrants found those with longer residence in Israel and higher insulinogenic index to have a threefold increase in the prevalence of hypertension in addition to acquiring higher cholesterol levels, indicating that in this ethnically distinct population environmental factors significantly affected the cardiovascular risk.
高胰岛素血症可能与高血压、高脂血症和葡萄糖耐量异常有关。在本研究中，我们比较了从埃塞俄比亚移民到以色列后的情况，以阐明环境因素对这些变量的影响。
对337名就读于寄宿学校的年轻埃塞俄比亚男性移民进行横断面分析，将他们分为两组：第一组在以色列停留时间<3个月（n = 180），第二组在以色列停留时间>2年（n = 157）。两组就读于同一学校，且从同一厨房用餐。
测量坐位血压、体重指数、肱三头肌皮褶厚度、空腹血脂、胰岛素和血糖水平，并进行标准（75g）口服葡萄糖耐量试验。
两组体重指数相似。第一组比第二组年轻。第二组的收缩压和舒张压均显著高于第一组。高血压在第二组中更为普遍。两组之间口服葡萄糖耐量试验的葡萄糖耐量受损患病率、糖化血红蛋白水平和果糖胺水平均无差异。第二组的胰岛素生成指数（口服葡萄糖耐量试验期间胰岛素曲线下面积与葡萄糖水平曲线下面积之比）显著更高。第二组的总胆固醇和高密度脂蛋白胆固醇水平显著更高。在逐步多元回归分析中，属于第二组且胰岛素生成指数较高可预测高血压。
这项对年轻、体型极瘦的埃塞俄比亚移民的横断面比较发现，在以色列居住时间较长且胰岛素生成指数较高的人群，除了胆固醇水平升高外，高血压患病率增加了两倍，这表明在这个种族不同的人群中，环境因素显著影响心血管风险。
