Peczyńska-Czoch W, Mordarski M, Kaczmarek L, Nantka-Namirski P
Arch Immunol Ther Exp (Warsz). 1986;34(3):327-31.
In the course of microbial transformation of the antitumor compounds, it has been found that iso-alpha-carbolines and their certain derivatives undergo N-1 methylation by Kitasatosporia setae. The resulting products, iso-alpha-carbolines exhibit antibacterial and antifungal properties in the concentration range of 0.2-2.5 mumol/ml. In the cytotoxicity test only derivatives substituted at C-2 and C-4 display moderate activity against KB cells. None of the compounds tested show a significant inhibitory effect against P388 lymphocytic leukemia.
在抗肿瘤化合物的微生物转化过程中，已发现异α-咔啉及其某些衍生物会被刺孢北里孢菌进行N-1甲基化。所得产物异α-咔啉在0.2 - 2.5 μmol/ml的浓度范围内表现出抗菌和抗真菌特性。在细胞毒性试验中，只有在C-2和C-4位被取代的衍生物对KB细胞表现出中等活性。所测试的化合物均未对P388淋巴细胞白血病显示出显著的抑制作用。
