Pan M C, Lin X Y, Wang H, Chen Y F, Leng M
Department of Burns, the Second Affiliated Hospital of Kunming Medical University, Kunming 650000, China.
Zhonghua Shao Shang Za Zhi. 2020 Sep 20;36(9):883-886. doi: 10.3760/cma.j.cn501120-20190702-00290.
Angiogenesis is the core step of wound repair, and vascular endothelial progenitor cells (EPC) play an extremely important role during wound repair. Recent studies have shown that vascular EPC-derived exosomes (EPC-Exo) can protect vessels, promote the proliferation and migration of vascular endothelial cells, and have anti-inflammatory, anti-oxidant and anti-apoptotic effects on vascular endothelial cells. This article reviews the mechanism of vascular EPC-Exo in angiogenesis and its potential applications in wound repair in recent years.
