Li Jiejie, Zhao Yuanyuan, Zhu Wei
Jiangsu Key Laboratory of Medical Science and Laboratory of Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.
Exp Ther Med. 2022 Jan;23(1):64. doi: 10.3892/etm.2021.10986. Epub 2021 Nov 22.
Acute myocardial infarction (AMI) remains the main cause of mortality worldwide. Despite surgery and medical treatment, the non-regeneration of dead cardiomyocytes and the limited contractile ability of scar tissue can lead to heart failure. Therefore, restoring blood flow in the infarcted area is important for the repair of myocardial injury. The objective of the present review was to summarize the factors influencing angiogenesis after AMI, and to describe the application of angiogenesis for cardiac repair. Collectively, this review may be helpful for relevant studies and to provide insight into future therapeutic applications in clinical practice.
急性心肌梗死（AMI）仍然是全球范围内主要的死亡原因。尽管有手术和药物治疗，但死亡心肌细胞的不可再生以及瘢痕组织有限的收缩能力会导致心力衰竭。因此，恢复梗死区域的血流对于心肌损伤的修复至关重要。本综述的目的是总结影响急性心肌梗死后血管生成的因素，并描述血管生成在心脏修复中的应用。总体而言，本综述可能有助于相关研究，并为临床实践中的未来治疗应用提供见解。
