Strozzi C, Cocco G, Portaluppi F, Urso L, Alfiero R, Tasini M T, Montanari L, Al Yassini K, Rizzo A
Cardiology. 1987;74(3):226-8. doi: 10.1159/000174201.
Twelve normotensive patients with coronary artery disease and stable effort-induced angina pectoris were selected: the antiischemic effect of captopril was studied. A maximal cycloergometer effort test was obtained before (base) and after administration of placebo or captopril (50 mg p.o.). The following parameters were measured: heart rate (HR), blood pressure (BP), maximal rate/pressure product (MRPP), maximal workload sustained, (MWS), maximal working time (MWT), and S-T depression at MRPP. The base and placebo were similar. Compared to them captopril augmented the MWT, increased the MWS, reduced S-T depression at MRPP, and decreased the number of patients with effort-induced angina pectoris. The antiischemic effect of captopril seems related both to its effect on HR and BP, and to a local enhancement of coronary blood flow.
选取了12例患有冠状动脉疾病且有稳定的劳力性心绞痛的血压正常患者：研究了卡托普利的抗缺血作用。在服用安慰剂或卡托普利（口服50毫克）之前（基础状态）和之后进行了最大运动功率计运动试验。测量了以下参数：心率（HR）、血压（BP）、最大心率/血压乘积（MRPP）、持续的最大工作量（MWS）、最大工作时间（MWT）以及在MRPP时的ST段压低。基础状态和安慰剂状态相似。与它们相比，卡托普利增加了MWT，提高了MWS，降低了MRPP时的ST段压低，并减少了劳力性心绞痛患者的数量。卡托普利的抗缺血作用似乎与其对HR和BP的作用以及局部冠状动脉血流的增强有关。
