Raz A, Ben-Ze'ev A
Cancer Metastasis Rev. 1987;6(1):3-21. doi: 10.1007/BF00047606.
The interaction of metastatic cells with the host environment occurs, to a large extent, through the cell surface, and the cell cytoskeletal system controls the distribution and motility of cell surface receptors. During metastasis, tumor cells migrate from one organ to another, and the dynamic properties and mechanochemical deformability of disseminated cells play a central role in the process. The studies described here under suggest an interrelationship between the cytoskeleton and cell adhesion, which can control and augment the expression of the metastatic phenotype of neoplastic cells.
转移细胞与宿主环境的相互作用在很大程度上通过细胞表面发生，而细胞细胞骨架系统控制着细胞表面受体的分布和运动。在转移过程中，肿瘤细胞从一个器官迁移到另一个器官，播散细胞的动态特性和机械化学可变形性在这一过程中起核心作用。本文所述研究表明细胞骨架与细胞黏附之间存在相互关系，这种关系可控制和增强肿瘤细胞转移表型的表达。
