整合素介导的信号转导及其在肿瘤生长调控中的作用。
Signal transduction by integrins and its role in the regulation of tumor growth.
作者信息
Juliano R
机构信息
Dept. of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill 27599.
出版信息
Cancer Metastasis Rev. 1994 Mar;13(1):25-30. doi: 10.1007/BF00690416.
It has become clear that integrins have effects on tumorigenesis that are in addition to their role in mediating cell adhesion during invasive and metastatic processes. Integrins can transduce signals from the extracellular matrix to cell interior, via tyrosine kinases, and possibly by other mechanisms as well. These integrin mediated signals contribute to control of gene expression, to regulation of anchorage-dependence, to cell cycle transit, and to the control of tumor growth.
很明显，整合素对肿瘤发生有影响，这是除了它们在侵袭和转移过程中介导细胞黏附的作用之外的。整合素可以通过酪氨酸激酶，也可能通过其他机制，将细胞外基质的信号转导至细胞内部。这些整合素介导的信号有助于控制基因表达、调节锚定依赖性、调控细胞周期进程以及控制肿瘤生长。
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