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[从巴拉圭医院血培养中分离出的菌种鉴定及药敏谱:巴拉圭医院血培养中分离出的菌种鉴定及药敏谱]

[Identification and susceptibility profile of species isolated from hemocultures in hospitals in ParaguayIdentificação e perfil de sensibilidade de spp. isoladas de hemoculturas em hospitais no Paraguai].

作者信息

Aguilar Gustavo, Araujo Patricia, Lird Graciela, Insaurralde Sonia, Kawabata Aníbal, Ayala Edelira, Irala Juan, Argüello Rocío

机构信息

Instituto de Previsión Social, Hospital Central Asunción Paraguay Instituto de Previsión Social, Hospital Central, Asunción, Paraguay.

Laboratorio Central de Salud Pública, Ministerio de Salud Asunción Paraguay Laboratorio Central de Salud Pública, Ministerio de Salud, Asunción, Paraguay.

出版信息

Rev Panam Salud Publica. 2020 Sep 23;44:e34. doi: 10.26633/RPSP.2020.34. eCollection 2020.

Abstract

OBJECTIVE

To report the species identified in candidemia isolated in hospitals in Paraguay, their distribution by age groups, and their susceptibility to fluconazole, voriconazole, and amphotericin B.

METHODS

Retrospective study of candidemia reported to the Central Health Public Laboratory by seven hospitals between 2010 and 2018. Identification and susceptibility testing were performed using the automated Vitek 2 system.

RESULTS

520 cases of candidiasis were reported. The prevalent species were (34.4%), (30.4%), (25.4% (4.8%), and (2.1%). Less frequent species were: (1.2%), (1%), (0.3%), (0.2%), and (0.2%). Candidiasis was most prevalent in the elderly (48.5%) and adults (29.9%). was most frequent in newborns and infants, and in pediatric patients; 2.8% and 0.6% of and 4.4% and 2.5% of were resistant, respectively, to fluconazole and voriconazole; 8% of were resistant to fluconazole and two isolations showed a minimum inhibitory concentration for voriconazole greater than 0.25 mg/L.

CONCLUSIONS

This is the first report on candidemias in hospitals of Paraguay. Together with other studies, it will improve knowledge about this infection in the country.

摘要

目的

报告在巴拉圭医院分离出的念珠菌血症中鉴定出的菌种、按年龄组的分布情况以及它们对氟康唑、伏立康唑和两性霉素B的敏感性。

方法

对2010年至2018年间七家医院向中央公共卫生实验室报告的念珠菌血症进行回顾性研究。使用自动化Vitek 2系统进行鉴定和药敏试验。

结果

报告了520例念珠菌病病例。常见菌种为[具体菌种1](34.4%)、[具体菌种2](30.4%)、[具体菌种3](25.4%)、[具体菌种4](4.8%)和[具体菌种5](2.1%)。较少见的菌种为:[具体菌种6](1.2%)、[具体菌种7](1%)、[具体菌种8](0.3%)、[具体菌种9](0.2%)和[具体菌种10](0.2%)。念珠菌病在老年人中最为常见(48.5%),在成年人中次之(29.9%)。[具体菌种]在新生儿和婴儿中最常见,[具体菌种]在儿科患者中最常见;[具体菌种1]和[具体菌种2]分别有2.8%和0.6%对氟康唑耐药,4.4%和2.5%对伏立康唑耐药;[具体菌种3]有8%对氟康唑耐药,两株分离菌对伏立康唑的最低抑菌浓度大于0.25mg/L。

结论

这是巴拉圭医院念珠菌血症的首次报告。与其他研究一起,将提高该国对这种感染的认识。

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