Wei Hongjuan, Chang Xin, Ji Rufeng, Tang Yinyan
Department of Pediatric, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, China.
Department of Ultrasound Medicine, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, China.
BMC Pregnancy Childbirth. 2025 May 13;25(1):563. doi: 10.1186/s12884-025-07706-w.
To investigate the association between late pregnancy A/G (Albumin to globulin) ratio and the risk of admission for neonatal hyperbilirubinemia (NHB).
This cross-sectional study selected mothers in labor and their newborns delivered at Nanjing Lishui People's Hospital, from January to December 2022. Multivariate logistic regression was utilized to analyze the relationship between late pregnancy A/G ratio and the risk of admission for NHB.
Out of 1432 pregnant women, 15.7% of newborns were admitted for NHB. Outcome 1: Dichotomizing the A/G ratio at 1.29, the risk of NHB admission decreased by 33% (95% CI: 0.46-0.97) for every 0.1 increase in A/G ratio < 1.29. Conversely, when the A/G ratio ≥ 1.29, the risk of NHB admission increased by 16% (95% CI: 1.01-1.32) for each 0.1 increase in A/G ratio. Outcome 2: When A/G ratio was categorized into three groups using thresholds of 1.15 and 1.40, the risk of NHB admission increased by 107% (95% CI: 1.17-3.66) for G1 and 60% (95% CI: 1.16-2.19) for G3, compared to G2.
Late pregnancy A/G ratio is closely associated with the risk of admission for NHB. A/G ratio within different ranges affects the risk of NHB in varying directions and to different extents. Monitoring the A/G ratio may help identify pregnancies at higher risk of NHB.
探讨妊娠晚期白蛋白/球蛋白（A/G）比值与新生儿高胆红素血症（NHB）入院风险之间的关联。
本横断面研究选取了2022年1月至12月在南京市溧水区人民医院分娩的产妇及其新生儿。采用多因素logistic回归分析妊娠晚期A/G比值与NHB入院风险之间的关系。
在1432名孕妇中，15.7%的新生儿因NHB入院。结果1：将A/G比值以1.29为界进行二分，当A/G比值<1.29时，每增加0.1，NHB入院风险降低33%（95%CI：0.46-0.97）。相反，当A/G比值≥1.29时，A/G比值每增加0.1，NHB入院风险增加16%（95%CI：1.01-1.32）。结果2：当使用1.15和1.40的阈值将A/G比值分为三组时，与G2组相比，G1组NHB入院风险增加107%（95%CI：1.17-3.66），G3组增加60%（95%CI：1.16-2.19）。
妊娠晚期A/G比值与NHB入院风险密切相关。不同范围内的A/G比值对NHB风险的影响方向和程度不同。监测A/G比值可能有助于识别NHB风险较高的妊娠。
