病例报告：缺血与迷走神经张力增加协同作用诱发一名Brugada综合征患者发生室颤
Case report: Synergetic effect of ischaemia and increased vagal tone inducing ventricular fibrillation in a patient with Brugada syndrome.
作者信息
Van Malderen Sophie C H, Schultz Carl J, Jordaens Luc
机构信息
Department of Cardiology, Erasmus MC, Dr. Molewaterplein 40. 3015 GD, Rotterdam, The Netherlands.
Department of Cardiology, AZ Monica, Florent Pauwelslei 1, 2100, Deurne, Belgium.
出版信息
Eur Heart J Case Rep. 2020 Jul 30;4(4):1-5. doi: 10.1093/ehjcr/ytaa202. eCollection 2020 Aug.
Abstract
BACKGROUND
Brugada syndrome (BS) is a hereditary channelopathy associated with syncope, malignant ventricular arrhythmia, and sudden cardiac death. Right ventricular ischaemia and BS have similar underlying substrates precipitating ventricular tachycardia or fibrillation (VF).
CASE SUMMARY
A 72-year-old woman with BS and a stenosis on the proximal right coronary artery received several subsequent implantable cardioverter-defibrillator shocks due to VF during an episode of extreme nausea with vomiting.
DISCUSSION
This case report emphasizes on the synergetic effect of mild ischaemia and increased vagal tone on the substrate responsible for BS to create pathophysiological changes precipitating VF.
摘要
背景
Brugada综合征（BS）是一种与晕厥、恶性室性心律失常及心源性猝死相关的遗传性离子通道病。右心室缺血与BS具有相似的引发室性心动过速或心室颤动（VF）的潜在机制。
病例摘要
一名72岁患有BS且右冠状动脉近端狭窄的女性，在一次伴有呕吐的极度恶心发作期间因VF接受了多次植入式心律转复除颤器电击。
讨论
本病例报告强调了轻度缺血和迷走神经张力增加对BS相关基质的协同作用，从而引发导致VF的病理生理变化。
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