抗σH因子RshA中的突变赋予了对益康唑和克霉唑的抗性。
Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in .
作者信息
Morbidoni Héctor R, de la Iglesia Agustina I, Figueroa Virginia, Di Capua Cecilia, Ioerger Thomas R, Parish Tanya
机构信息
Laboratorio de Microbiología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Argentina.
Present address: Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina.
出版信息
Access Microbiol. 2019 Oct 29;1(10):e000070. doi: 10.1099/acmi.0.000070. eCollection 2019.
Azole drugs such as econazole, are active on and ; however, the identification of their target(s) is still pending. It has been reported that mutations in the non-essential system L5-S5 conferred resistance to econazole in . We herein report that an azole-resistant mutant screen in rendered mutations in A, encoding a non-essential anti-sigma H protein.
诸如益康唑之类的唑类药物对[具体对象1]和[具体对象2]有活性；然而，它们的靶点鉴定仍未完成。据报道，非必需系统L5 - S5中的突变赋予了[具体对象3]对益康唑的抗性。我们在此报告，在[具体对象4]中进行的唑类抗性突变体筛选导致了编码非必需抗σH蛋白的A基因突变。
Zotero 插件