Cosmetic Ingredient Review Senior Director, Washington, DC, USA.
Expert Panel for Cosmetic Ingredient Safety Member, Washington, DC, USA.
Int J Toxicol. 2020 Sep;39(2_suppl):26S-58S. doi: 10.1177/1091581820951557.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 60 PEGylated alkyl glycerides. PEGylated alkyl glycerides are mono-, di-, and/or triglycerides that have been modified with ethylene glycol repeat units (in the starting material form as epoxide). Most of the PEGylated alkyl glycerides are reported to function as skin-conditioning agents or surfactants. The Panel reviewed the available animal and clinical data as well as data from the 1999 report for the 5 polyethylene glycol (PEG) glyceryl cocoates and the 2012 report of PEGylated oils, to determine the safety of these ingredients. The Panel concluded these ingredients are safe in the current practices of use and concentration when formulated to be nonirritating; this conclusion supersedes the 1999 conclusion issued on 5 PEG glyceryl cocoate ingredients.
专家组对 60 种聚乙二醇化烷基甘油酯的安全性进行了评估。聚乙二醇化烷基甘油酯是经过修饰的单、双和/或三甘油酯，其中含有乙二醇重复单元（起始物质形式为环氧化物）。大多数聚乙二醇化烷基甘油酯被报告为具有调理皮肤或表面活性剂的功能。专家组审查了现有的动物和临床数据以及 1999 年关于 5 种聚乙二醇（PEG）椰油醇酯和 2012 年关于聚乙二醇化油的报告的数据，以确定这些成分的安全性。专家组得出结论，这些成分在目前的使用方式和浓度下是安全的，前提是配方为非刺激性；这一结论取代了 1999 年就 5 种聚乙二醇椰油醇酯成分发布的结论。
