开放痔切除术后聚卡波非和裂解物凝胶的短期疗效：一项前瞻性队列研究。

Short-Term Outcomes of Polycarbophil and Lysate Gel after Open Hemorrhoidectomy: A Prospective Cohort Study.

作者信息

Gallo Gaetano, Grossi Ugo, Di Tanna Gian Luca, Santoro Giulio Aniello, De Paola Gilda, Clerico Giuseppe, Realis Luc Alberto, Trompetto Mario, Sammarco Giuseppe

机构信息

Department of Medical and Surgical Sciences, University of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.

Tertiary Referral Pelvic Floor Center, IV Surgery Unit, Treviso Regional Hospital, DISCOG, University of Padua, 31100 Treviso, Italy.

出版信息

J Clin Med. 2020 Dec 10;9(12):3996. doi: 10.3390/jcm9123996.

DOI:10.3390/jcm9123996

PMID:33321707

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7763882/

Abstract

BACKGROUND

Pain is the most common complication after open excisional hemorrhoidectomy (OEH). We assessed the effectiveness of polycarbophil and lysate gel (EmorsanGel) on pain control after OEH.

RESEARCH DESIGN AND METHODS

Fifty consecutive patients undergoing OEH were included. All patients received stool softeners and oral analgesia in the post-operative period. EmorsanGel was also used topically by the last 25 patients (EmorsanGel group (EG)) until Post-Operative Day 20 (POD 20). The primary outcome was the effectiveness of EmorsanGel on pain relief using an 11-point visual analogue scale (VAS). Morbidity, wound healing (WH), and time to work were documented at POD 1, POD 10, POD 20, and POD 40.

RESULTS

Of the 50 patients enrolled, twenty-eight (56%) were males; median age, 49 (range, 28-73) years. The VAS score decreased over time in all patients, with significantly lower scores at POD 20 in the EG (1.44 (SD, 1.16) vs. 2.12 (0.93) in the control group (CG); = 0.045). All patients in the EG achieved complete WH at last follow-up, compared to only 17 (68%) in the CG ( = 0.004). The likelihood of WH was 66% higher in the EG (OR, 1.66 [95%CI, 0.80-3.44; = 0.172).

CONCLUSIONS

EmorsanGel is safe and effective at reducing pain after EOH, promoting earlier WH compared to standard care treatment.

摘要

背景

疼痛是开放性痔切除术（OEH）后最常见的并发症。我们评估了聚卡波非和裂解物凝胶（EmorsanGel）在OEH后疼痛控制方面的有效性。

研究设计与方法

纳入50例连续接受OEH的患者。所有患者术后均接受了大便软化剂和口服镇痛治疗。最后25例患者（EmorsanGel组（EG））还在术后第20天（POD 20）前局部使用EmorsanGel。主要结局是使用11点视觉模拟量表（VAS）评估EmorsanGel缓解疼痛的有效性。在POD 1、POD 10、POD 20和POD 40记录发病率、伤口愈合情况（WH）和恢复工作时间。

结果

在纳入的50例患者中，28例（56%）为男性；中位年龄49岁（范围28 - 73岁）。所有患者的VAS评分随时间下降，EG组在POD 20时的评分显著低于对照组（CG）（1.44（标准差，1.16）对2.12（0.93）；P = 0.045）。EG组所有患者在最后一次随访时均实现了完全伤口愈合，而CG组只有17例（68%）（P = 0.004）。EG组伤口愈合的可能性比CG组高66%（比值比，1.66 [95%置信区间，0.80 - 3.44；P = 0.172]）。