Centre for Precision Therapeutics, NeuroGen Children's Healthcare, Dhaka, Bangladesh.
Genetics and Genomic Medicine Centre, NeuroGen Children's Healthcare, Dhaka, Bangladesh.
J Autism Dev Disord. 2021 Jul;51(7):2392-2401. doi: 10.1007/s10803-020-04703-0.
This study explored the physical and clinical phenotype of Bangladeshi children with autism spectrum disorder (ASD). A totally of 283 children who were referred for screening and administered Module 1 of the Autism Diagnostic Observation Schedule (ADOS) were included. Overall, 209 met the ADOS algorithmic cutoff for ASD. A trend for greater weight and head circumference was observed in children with ASD versus non-ASD. Head circumference was significantly (p < 0.03) larger in ASD males compared with non-ASD males. A trend was also observed for symptom severity, higher in females than males (p = 0.068), with further analyses demonstrating that social reciprocity (p < 0.014) and functional play (p < 0.03) were significantly more impaired in ASD females than males. The findings help understand sex differences in ASD.
本研究旨在探索孟加拉国自闭症谱系障碍（ASD）儿童的身体和临床表型。共纳入 283 名经筛查并接受自闭症诊断观察量表（ADOS）模块 1 评估的儿童。总体而言，有 209 名儿童符合 ADOS 的 ASD 算法截断值。与非 ASD 儿童相比，ASD 儿童的体重和头围呈上升趋势。ASD 男性的头围明显大于非 ASD 男性（p<0.03）。还观察到症状严重程度存在趋势，女性高于男性（p=0.068），进一步分析表明，ASD 女性的社会互惠（p<0.014）和功能性游戏（p<0.03）明显比男性受损更严重。这些发现有助于理解 ASD 中的性别差异。
