Chantelau E, Lange G, Gasthaus M, Boxberger M, Berger M
Diabetes Care. 1987 May-Jun;10(3):348-51. doi: 10.2337/diacare.10.3.348.
In search of possible interactions between plastic tubings used for insulin-pump treatment and commercial regular insulin preparations, various catheter sets made from polyvinyl chloride (PVC), polyethylene (PE), and nylon plastics were perfused at 30 degrees C in a laboratory setting for up to 72 h. The perfused insulin solutions were analyzed by high-performance liquid chromatography and atomic absorption spectroscopy. Although no plasticizer, e.g., dioctyl phthalate, or nickel or chromium ions were found in the perfusates, substantial interactions between the plastics and the insulin solutions were detected, extraction of bacteriostatic additives from the insulin solutions in particular. The PVC retained up to 88% of the bacteriostatics from the insulin preparations, whereas PE tubings retained only 10-15%. Whether the loss of preservatives during perfusion through PVC catheters predisposes to cutaneous infections during insulin-pump therapy remains to be shown.
为了探寻用于胰岛素泵治疗的塑料管材与市售常规胰岛素制剂之间可能存在的相互作用，在实验室环境中，将由聚氯乙烯（PVC）、聚乙烯（PE）和尼龙塑料制成的各种导管套件在30摄氏度下灌注长达72小时。通过高效液相色谱法和原子吸收光谱法对灌注后的胰岛素溶液进行分析。尽管在灌注液中未发现增塑剂（如邻苯二甲酸二辛酯）、镍或铬离子，但检测到塑料与胰岛素溶液之间存在大量相互作用，尤其是从胰岛素溶液中提取抑菌添加剂。PVC可保留胰岛素制剂中高达88%的抑菌剂，而PE管材仅保留10%-15%。通过PVC导管灌注期间防腐剂的损失是否会导致胰岛素泵治疗期间皮肤感染，仍有待证实。
