Smith A, Bird G
J Clin Hosp Pharm. 1982 Sep;7(3):181-6. doi: 10.1111/j.1365-2710.1982.tb01021.x.
A significant interaction exists between diazepam and infusion fluid containers constructed of PVC plastics. This is attributed to absorption of the drug into the PVC matrix and should preclude the use of this type of container prior to or during infusion of diazepam admixtures. Infusions containing diazepam injection either as a solution (in dextrose 5% or sodium chloride 0.9%) or oil-in-water emulsion (in dextrose 5%) exhibit no significant interaction over 48 h when prepared in polyethylene (Polyfusor) containers. No data were obtained regarding the physical stability of diluted emulsion. The inert nature of polyethylene and an absence of plasticizers or other additives account for a good compatibility with the drug additive. Therefore, diazepam dilutions may be prepared in polyethylene containers as an alternative to glass. However, the interaction with administration sets should not be overlooked when considering these solutions for infusion.
地西泮与由聚氯乙烯（PVC）塑料制成的输液容器之间存在显著相互作用。这归因于药物被吸收到PVC基质中，因此在输注地西泮 admixtures之前或期间应避免使用此类容器。当在聚乙烯（聚输液器）容器中制备时，含有地西泮注射液的溶液（5%葡萄糖或0.9%氯化钠中）或水包油乳剂（5%葡萄糖中）在48小时内未表现出显著相互作用。未获得关于稀释乳剂物理稳定性的数据。聚乙烯的惰性以及不存在增塑剂或其他添加剂使得其与药物添加剂具有良好的相容性。因此，地西泮稀释液可在聚乙烯容器中制备，作为玻璃容器的替代选择。然而，在考虑这些用于输注的溶液时，与给药装置的相互作用不应被忽视。
