Department of Stroke Treatment, Shonan Kamakura General Hospital, Okamoto 1370-1, Kamakura City, Kanagawa 247-8533, Japan.
Nutrients. 2020 Sep 23;12(10):2903. doi: 10.3390/nu12102903.
Dietary triglycerides influence the serum concentrations of fatty acids (FA) and their weight percentages (wt%), which might be associated with the age of onset of intracerebral hemorrhage (ICH). We investigated the correlation between serum FA levels and proportions at admission, and the age at onset of ICH. We included patients admitted between 2016 and 2019 within 24 h of the onset of ICH, and calculated the correlation coefficients between their age, serum FA concentration, and FA wt%. We performed multiple linear regression analysis to identify individual FAs related to the age at onset of ICH. Furthermore, we estimated the threshold values of FAs that were independently associated with the age at onset of ICH <65 years, using receiver operating characteristic curves by logistic regression. Our inclusion criteria were met by 141 patients (mean age, 67 years). The concentration of dihomo-gamma-linolenic acid (DGLA) and the wt% of eicosapentaenoic acid (EPA) were significant independent variables for the age at onset of ICH. The ROC curves for the age of onset <65 years were ≥108.6 µmol/L for DGLA and ≤1.7% for EPA. Increased DGLA concentration and decreased EPA wt% were significantly associated with young-onset ICH.
饮食中的甘油三酯会影响血清脂肪酸（FA）的浓度及其重量百分比（wt%），这可能与脑出血（ICH）的发病年龄有关。我们研究了入院时血清 FA 水平和比例与 ICH 发病年龄之间的相关性。我们纳入了 2016 年至 2019 年期间发病后 24 小时内入院的患者，并计算了他们的年龄、血清 FA 浓度和 FA wt%之间的相关系数。我们进行了多元线性回归分析，以确定与 ICH 发病年龄相关的个体 FA。此外，我们通过逻辑回归的受试者工作特征曲线，估计了与 <65 岁发病年龄独立相关的 FA 的阈值。符合我们纳入标准的患者有 141 例（平均年龄 67 岁）。二高-γ-亚麻酸（DGLA）的浓度和二十碳五烯酸（EPA）的 wt%是 ICH 发病年龄的显著独立变量。对于发病年龄<65 岁的 ROC 曲线，DGLA 的阈值≥108.6µmol/L，EPA 的阈值≤1.7%。DGLA 浓度的增加和 EPA wt%的降低与早发性 ICH 显著相关。
