Department of Stroke Treatment, Shonan Kamakura General Hospital, Okamoto 1370-1, Kamakura City, Japan.
Nutrients. 2020 Aug 12;12(8):2411. doi: 10.3390/nu12082411.
Dietary triglycerides influence fatty acid (FA) serum concentrations and weight percentages (wt %), which may be associated with the age of onset of acute ischemic stroke (AIS). We investigated the correlations between serum FA levels and proportions at admission and the age of onset of AIS. We evaluated patients with AIS admitted between 2016 and 2019 within 24 h of AIS onset and calculated the correlation coefficients between their ages, serum FA concentrations, and FA wt % values. Multiple linear regression analysis was performed to identify independent FAs indicating AIS age of onset. Furthermore, we estimated the threshold values of independent FAs for age of onset <60 years using receiver operating characteristic curves by logistic regression. A total of 525 patients (median age: 75 years) met the inclusion criteria. The concentration of dihomo-gamma-linolenic acid (DGLA) and wt % of docosahexaenoic acid (DHA) were significant independent variables for age of onset of AIS, and receiver operating characteristic curves for age of onset <60 years showed thresholds of ≥117.7 µmol/L for DGLA and ≤3.7% for DHA. An increased DGLA concentration and decreased DHA wt % were significantly associated with onset of AIS at a younger age.
饮食中的甘油三酯会影响脂肪酸（FA）在血清中的浓度和重量百分比（wt%），这可能与急性缺血性脑卒中（AIS）的发病年龄有关。我们研究了入院时血清 FA 水平和比例与 AIS 发病年龄之间的相关性。我们评估了 2016 年至 2019 年期间 AIS 发病后 24 小时内入院的 AIS 患者，并计算了他们的年龄、血清 FA 浓度和 FA wt%值之间的相关系数。进行多元线性回归分析以确定表明 AIS 发病年龄的独立 FA。此外，我们通过 logistic 回归的Receiver Operating Characteristic（ROC）曲线估计独立 FA 对发病年龄<60 岁的阈值。共有 525 名患者（中位年龄：75 岁）符合纳入标准。二高-γ-亚麻酸（DGLA）的浓度和二十二碳六烯酸（DHA）的 wt%是 AIS 发病年龄的显著独立变量，ROC 曲线显示发病年龄<60 岁的 DGLA 阈值≥117.7µmol/L，DHA 的阈值≤3.7%。较高的 DGLA 浓度和较低的 DHA wt%与发病年龄较轻显著相关。
