Lab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
Research Center for Special Medicine and Health Systems Engineering, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
Int J Mol Sci. 2020 Sep 23;21(19):6985. doi: 10.3390/ijms21196985.
The bone microenvironment is an ideal fertile soil for both primary and secondary tumors to seed. The occurrence and development of osteosarcoma, as a primary bone tumor, is closely related to the bone microenvironment. Especially, the metastasis of osteosarcoma is the remaining challenge of therapy and poor prognosis. Increasing evidence focuses on the relationship between the bone microenvironment and osteosarcoma metastasis. Many elements exist in the bone microenvironment, such as acids, hypoxia, and chemokines, which have been verified to affect the progression and malignance of osteosarcoma through various signaling pathways. We thoroughly summarized all these regulators in the bone microenvironment and the transmission cascades, accordingly, attempting to furnish hints for inhibiting osteosarcoma metastasis via the amelioration of the bone microenvironment. In addition, analysis of the cross-talk between the bone microenvironment and osteosarcoma will help us to deeply understand the development of osteosarcoma. The cellular and molecular protagonists presented in the bone microenvironment promoting osteosarcoma metastasis will accelerate the exploration of novel therapeutic strategies towards osteosarcoma.
骨微环境是原发性和继发性肿瘤播种的理想肥沃土壤。骨肉瘤作为一种原发性骨肿瘤的发生和发展与骨微环境密切相关。特别是骨肉瘤的转移仍然是治疗的挑战和预后不良的原因。越来越多的证据集中在骨微环境与骨肉瘤转移之间的关系上。骨微环境中存在许多元素，如酸、缺氧和趋化因子，它们已被证明通过各种信号通路影响骨肉瘤的进展和恶性程度。我们全面总结了骨微环境中的所有这些调节剂及其传递级联，从而试图通过改善骨微环境来抑制骨肉瘤转移提供线索。此外，分析骨微环境与骨肉瘤之间的串扰将有助于我们深入了解骨肉瘤的发展。在骨微环境中促进骨肉瘤转移的细胞和分子主要参与者将加速探索针对骨肉瘤的新型治疗策略。
Zotero 插件