血清素对十二指肠脂肪抑制胃蛋白酶的影响。
The effect of serotonin on pepsin inhibition by duodenal fat.
作者信息
Wazna M F, Stein T, Wise L
出版信息
Ann Surg. 1977 Aug;186(2):130-5. doi: 10.1097/00000658-197708000-00002.
The purpose of these studies was to evaluate the possible role of serotonin on pepsin secretion. The results of our data suggest that serotonin is a stimulator of pepsin secretion since (a) pretreatment with reserpine (which depletes serotonin stores) abolished the stimulatory effect of histamine on pepsin secretion; (b) pretreatment with UML-491 (a serotonin blocking agent at the effector level) augmented the pepsin inhibition induced by the intraduodenal infusion of fat, and (c) 5-hydroxytryptophan (a serotonin precursor) caused a significant stimulation of pepsin secretion. The mode of action of serotonin is probably by a direct hormonal action on the gastric chief cells.
这些研究的目的是评估血清素在胃蛋白酶分泌中可能发挥的作用。我们的数据结果表明，血清素是胃蛋白酶分泌的刺激物，因为：（a）用利血平（可耗尽血清素储备）进行预处理消除了组胺对胃蛋白酶分泌的刺激作用；（b）用UML-491（一种在效应器水平阻断血清素的药物）进行预处理增强了十二指肠内注入脂肪所诱导的胃蛋白酶抑制作用；以及（c）5-羟色氨酸（一种血清素前体）引起了胃蛋白酶分泌的显著刺激。血清素的作用方式可能是对胃主细胞的直接激素作用。
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