Maumy Louise, Salakos Eleonora, Rocher Grégoire, Al Mamari Thuraya, Bonneau Claire, Elies Antoine, Neuzillet Cindy, Rouzier Roman
Institut Curie, 35, rue Dailly, 92210 Saint-Cloud, France.
Institut Curie, 35, rue Dailly, 92210 Saint-Cloud, France; Université de Versailles SQY, université Paris Saclay, UFR des sciences de la santé Simone-Veil, Paris, France.
Bull Cancer. 2020 Oct;107(10):1042-1055. doi: 10.1016/j.bulcan.2020.06.013. Epub 2020 Sep 22.
The benefits of physical activity (PA) in breast cancer are currently recognized in primary prevention. The World Cancer Research Fund (WCRF) and then the National Cancer Institute (INCa) have reported conflicting results regarding the impact of post-diagnosis PA on breast cancer outcomes. The aim of this systematic review is to assess the association between PA after breast cancer diagnosis and overall mortality, specific mortality and risk of breast cancer recurrence in the literature.
Randomized trials, prospective cohorts and meta-analyses studying post-diagnosis PA and overall mortality, breast cancer mortality or risk of recurrence after breast cancer published between January 1, 2014 and October 1, 2019 were included. The articles selected by the INCa report prior to 2014 were included in the literature review.
Eighteen articles have been selected. Studies unanimously concluded that overall mortality was reduced by post-diagnosis PA practice. For specific mortality, 5 meta-analyses showed a significant decrease in breast cancer mortality and 2 found a decrease in the risk of recurrence.
Post-diagnosis PA reduces overall mortality and appears to impact specific breast cancer mortality and risk of recurrence. However, these results need to be confirmed by larger randomized trials.
体育活动（PA）在乳腺癌一级预防中的益处目前已得到认可。世界癌症研究基金会（WCRF）以及随后的法国国家癌症研究所（INCa）就诊断后体育活动对乳腺癌预后的影响报告了相互矛盾的结果。本系统评价的目的是评估文献中乳腺癌诊断后体育活动与总死亡率、特定死亡率以及乳腺癌复发风险之间的关联。
纳入2014年1月1日至2019年10月1日期间发表的研究诊断后体育活动与总死亡率、乳腺癌死亡率或乳腺癌复发风险的随机试验、前瞻性队列研究和荟萃分析。2014年之前法国国家癌症研究所报告中所选的文章也纳入文献综述。
共筛选出18篇文章。研究一致得出结论，诊断后进行体育活动可降低总死亡率。对于特定死亡率，5项荟萃分析显示乳腺癌死亡率显著降低，2项发现复发风险降低。
诊断后进行体育活动可降低总死亡率，且似乎对特定的乳腺癌死亡率和复发风险有影响。然而，这些结果需要通过更大规模的随机试验来证实。
