Division of Cancer Epidemiology, Department of Clinical Sciences, Lund University, Lund, Sweden.
Division of Cancer Epidemiology and Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.
Eur J Cancer Care (Engl). 2019 Jul;28(4):e13037. doi: 10.1111/ecc.13037. Epub 2019 Mar 21.
Physical activity (PA) leads to improved survival in women following the diagnosis of breast cancer, but it is less clear whether PA has equally positive effects regardless of age at diagnosis. The purpose of our study was to evaluate the association between post-diagnosis PA and survival in women aged below or over 55 years at diagnosis.
From a prospective population-based cohort of Swedish women, we included 847 women, aged 34-84 years, who were diagnosed with breast cancer from 1992 to 2012. A PA score was calculated based on three different questions regarding self-reported PA. Cox proportional hazard model was used to estimate the association between PA and mortality.
A significant association between PA score and all-cause mortality was observed, in a dose-response manner (p = 0.01). The mortality was clearly lower in the most active compared to the least active group (hazard ratio 0.29, 95% confidence intervals 0.09-0.90). A subgroup analysis showed that the improved survival was only seen in women over 55 years of age at diagnosis.
Physical activity, which is a modifiable lifestyle factor, should be encouraged after breast cancer diagnosis, especially in women with post-menopausal breast cancer.
体力活动（PA）可改善女性乳腺癌诊断后的生存状况，但目前尚不清楚体力活动是否无论诊断时的年龄如何，都能产生同样积极的影响。我们的研究目的是评估诊断后体力活动与 55 岁以下和以上女性生存之间的关联。
我们从瑞典前瞻性基于人群的女性队列中纳入了 847 名年龄在 34-84 岁之间、1992 年至 2012 年间被诊断患有乳腺癌的女性。根据三个关于自我报告体力活动的不同问题计算体力活动评分。使用 Cox 比例风险模型来估计体力活动与死亡率之间的关联。
体力活动评分与全因死亡率呈显著相关性，呈剂量反应关系（p=0.01）。与最不活跃组相比，最活跃组的死亡率明显较低（风险比 0.29，95%置信区间 0.09-0.90）。亚组分析显示，生存改善仅见于诊断时年龄超过 55 岁的女性。
体力活动是一种可改变的生活方式因素，乳腺癌诊断后应鼓励进行体力活动，尤其是对于绝经后患有乳腺癌的女性。
