circ_HIPK3 通过 miR-582-3p/DLX2 轴抑制肝细胞癌的肿瘤发生。
Knockdown of circ_HIPK3 inhibits tumorigenesis of hepatocellular carcinoma via the miR-582-3p/DLX2 axis.
机构信息
Department of Laboratory Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, 510630, China.
Department of Pediatric, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, 510630, China.
出版信息
Biochem Biophys Res Commun. 2020 Dec 10;533(3):501-509. doi: 10.1016/j.bbrc.2020.09.050. Epub 2020 Sep 22.
Hepatocellular carcinoma (HCC) is the most common type in the sub-classification of liver cancer. Circular RNAs (circRNAs) play a fundamental role in tumor occurrence and progression. This research aimed to investigate the role and molecular basis of circRNA homeodomain-interacting protein kinase 3 (circ_HIPK3) in HCC. Circ_HIPK3 and DLX2 levels were enhanced, and miR-582-3p level was reduced in HCC tissues and cells. Silencing of circ_HIPK3 impeded proliferation, migration and invasion and expedited apoptosis in HCC cells. Furthermore, circ_HIPK3 modulated HCC progression via sponging miR-582-3p, and miR-582-3p suppressed HCC progression via targeting DLX2. Moreover, circ_HIPK3 knockdown inhibited tumor growth in vivo. Circ_HIPK3 facilitated HCC progression by mediating miR-582-3p/DLX2 pathway, suggesting a new potential biomarker for HCC treatment.
肝细胞癌（HCC）是肝癌分类中的最常见类型。环状 RNA（circRNA）在肿瘤发生和发展中起着重要作用。本研究旨在探讨 circRNA 同源结构域相互作用蛋白激酶 3（circ_HIPK3）在 HCC 中的作用和分子基础。circ_HIPK3 和 DLX2 水平在 HCC 组织和细胞中升高，miR-582-3p 水平降低。沉默 circ_HIPK3 可抑制 HCC 细胞的增殖、迁移和侵袭，并促进其凋亡。此外，circ_HIPK3 通过海绵吸附 miR-582-3p 来调节 HCC 的进展，而 miR-582-3p 通过靶向 DLX2 抑制 HCC 的进展。此外，circ_HIPK3 敲低可抑制体内肿瘤生长。circ_HIPK3 通过介导 miR-582-3p/DLX2 通路促进 HCC 进展，提示其可能成为 HCC 治疗的新潜在生物标志物。
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