Department of Oral & Maxillofacial Clinical Sciences, Faculty of Dentistry, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Oral Cancer Research & Coordinating Centre, Faculty of Dentistry, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Head Neck Pathol. 2023 Mar;17(1):218-232. doi: 10.1007/s12105-022-01481-2. Epub 2022 Nov 7.
Homeobox genes play crucial roles in tooth morphogenesis and development and thus mutations in homeobox genes cause developmental disorders such as odontogenic lesions. The aim of this scoping review is to identify and compile available data from the literatures on the topic of homeobox gene expression in odontogenic lesions.
An electronic search to collate all the information on studies on homeobox gene expression in odontogenic lesions was carried out in four databases (PubMed, EBSCO host, Web of Science and Cochrane Library) with selected keywords. All papers which reported expression of homeobox genes in odontogenic lesions were considered.
A total of eleven (11) papers describing expression of homeobox genes in odontogenic lesions were identified. Methods of studies included next generation sequencing, microarray analysis, RT-PCR, Western blotting, in situ hybridization, and immunohistochemistry. The homeobox reported in odontogenic lesions includes LHX8 and DLX3 in odontoma; PITX2, MSX1, MSX2, DLX, DLX2, DLX3, DLX4, DLX5, DLX6, ISL1, OCT4 and HOX C in ameloblastoma; OCT4 in adenomatoid odontogenic tumour; PITX2 and MSX2 in primordial odontogenic tumour; PAX9 and BARX1 in odontogenic keratocyst; PITX2, ZEB1 and MEIS2 in ameloblastic carcinoma while there is absence of DLX2, DLX3 and MSX2 in clear cell odontogenic carcinoma.
This paper summarized and reviews the possible link between homeobox gene expression in odontogenic lesions. Based on the current available data, there are insufficient evidence to support any definite role of homeobox gene in odontogenic lesions.
同源盒基因在牙齿形态发生和发育中起着至关重要的作用，因此同源盒基因突变会导致发育障碍，如牙源性病变。本综述的目的是确定并汇编有关牙源性病变中同源盒基因表达的文献中的可用数据。
在四个数据库（PubMed、EBSCOhost、Web of Science 和 Cochrane Library）中进行电子搜索，以收集有关牙源性病变中同源盒基因表达的所有信息，并使用选定的关键词进行搜索。所有报告牙源性病变中同源盒基因表达的论文均被认为是相关的。
共确定了 11 篇描述牙源性病变中同源盒基因表达的论文。研究方法包括下一代测序、微阵列分析、RT-PCR、Western blot、原位杂交和免疫组织化学。在牙源性病变中报告的同源盒包括牙瘤中的 LHX8 和 DLX3；成釉细胞瘤中的 PITX2、MSX1、MSX2、DLX、DLX2、DLX3、DLX4、DLX5、DLX6、ISL1、OCT4 和 HOX C；牙源性腺样瘤中的 OCT4；原始性牙源性肿瘤中的 PITX2 和 MSX2；牙源性角化囊肿中的 PAX9 和 BARX1；成釉细胞瘤中的 PITX2、ZEB1 和 MEIS2，而透明细胞牙源性癌中则缺乏 DLX2、DLX3 和 MSX2。
本文总结和回顾了牙源性病变中同源盒基因表达之间的可能联系。基于目前可用的数据，没有足够的证据支持同源盒基因在牙源性病变中发挥任何明确的作用。
