Kessler Foundation, Rocco Ortenzio Neuroimaging Center, 1199 Pleasant Valley Way, West Orange, NJ, 07052, USA.
Department of Physical Medicine and Rehabilitation, Rutgers-NJ Medical School, Newark, NJ, USA.
Brain Topogr. 2020 Nov;33(6):776-784. doi: 10.1007/s10548-020-00798-x. Epub 2020 Sep 25.
Our objective was to determine differences in brain activation during a processing-speed task in individuals with SCI compared to a group of age-matched healthy controls and to a group of older healthy controls. Ten individuals with cervical SCI (C3-C5), 10 age-matched healthy controls and 10 older healthy controls participated in a cross-sectional study in which performance on neuropsychological tests of processing speed and brain activation were the main outcome measures. The brain areas used by the individuals with SCI during the processing-speed task differed significantly from the age-matched healthy controls, but were similar to the older control cohort, and included activation in frontal, parietal and hippocampal areas. This suggests that individuals with SCI may compensate for processing-speed deficits by relying on brain regions that classically support control cognitive processes such as executive control and memory.
我们的目的是确定与年龄匹配的健康对照组和老年健康对照组相比，脊髓损伤（SCI）个体在执行速度任务时大脑激活的差异。10 名颈段 SCI（C3-C5）患者、10 名年龄匹配的健康对照组和 10 名老年健康对照组参加了一项横断面研究，其中执行速度的神经心理学测试和大脑激活是主要的结果测量指标。在执行速度任务中，SCI 患者使用的大脑区域与年龄匹配的健康对照组有显著差异，但与老年对照组相似，包括额叶、顶叶和海马区域的激活。这表明，SCI 患者可能通过依赖于经典支持控制认知过程（如执行控制和记忆）的大脑区域来补偿执行速度缺陷。
