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2014 年至 2017 年期间,英国媒体对荷尔蒙避孕药物不良反应报道的增加与药物不良事件报告之间的共同出现。

The cooccurrence of heightened media attention and adverse drug reaction reports for hormonal contraception in the United Kingdom between 2014 and 2017.

机构信息

University of Utrecht, Netherlands.

University of Reading, United Kingdom.

出版信息

Br J Clin Pharmacol. 2021 Apr;87(4):1768-1777. doi: 10.1111/bcp.14563. Epub 2020 Nov 2.

Abstract

AIM

The aim of this study was to examine the cooccurrence of heightened media attention after the publication of a paper by Skovlund et al in September 2016 on the link between hormonal contraception and depression or mood on adverse drug reaction (ADR) reports in the UK.

METHODS

A quantitative analysis of relevant newspaper articles published between January 2014 and December 2017 was performed, as well as a content analysis. ADR reports were collected from the Medicines and Healthcare Products Regulatory Agency website and via a Freedom of Information request. A quantitative analysis was performed on ADR reports of hormonal contraceptives for all ADRs and for depressed mood disorders and disturbances.

RESULTS

The publication of the Skovlund et al paper did not lead to a peak in relevant newspaper articles, but there was a change in the content of the newspaper articles, which focussed more on the link between hormonal contraceptives and depression or mood. There was an overall increase in ADR reports by women relating to hormonal contraceptives between 2016 and 2017, and for combined contraceptives this was due to an increase in ADR reports of depressed mood disorders and disturbances.

CONCLUSIONS

The content of media attention appears to affect ADR reporting by women for combined contraceptives. In general, patients report the majority of depressed mood disorders and disturbances ADRs as opposed to health professionals, who report other ADRs. Care providers can anticipate the effect of heightened media attention and help patients when they experience these ADRs.

摘要

目的

本研究旨在探讨 2016 年 9 月 Skovlund 等人发表的关于激素避孕与抑郁或情绪不良药物不良反应(ADR)报告之间关联的论文发表后,媒体关注度的增加是否会对英国的 ADR 报告产生影响。

方法

对 2014 年 1 月至 2017 年 12 月期间发表的相关报纸文章进行了定量分析和内容分析。ADR 报告从药品和保健品管理局网站和信息自由请求中收集。对激素避孕药的所有 ADR 和抑郁情绪障碍和紊乱的 ADR 报告进行了定量分析。

结果

Skovlund 等人的论文发表并没有导致相关报纸文章的高峰,但报纸文章的内容发生了变化,更多地关注了激素避孕药与抑郁或情绪之间的联系。2016 年至 2017 年间,与激素避孕药相关的女性 ADR 报告总体增加,而复方避孕药的 ADR 报告增加则是由于抑郁情绪障碍和紊乱的 ADR 报告增加。

结论

媒体关注度的内容似乎影响了女性对复方避孕药的 ADR 报告。总的来说,患者比健康专业人员更报告大多数抑郁情绪障碍和紊乱的 ADR,而健康专业人员报告其他 ADR。护理提供者可以预测媒体关注度增加的影响,并在患者出现这些 ADR 时为他们提供帮助。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bba/8056733/ab6e9abbacd9/BCP-87-1768-g003.jpg

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