Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, 602 Tower Rd, Ithaca, NY 14853, USA; Department of Small Animal Medicine and Surgery, The University of Georgia, 2200 College Station Rd, Athens, GA 30605, USA.
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, 602 Tower Rd, Ithaca, NY 14853, USA; Lloyd Veterinary Medical Center, College of Veterinary Medicine, Iowa state University, 1809 S Riverside Drive, Ames, IA 50011, USA.
Res Vet Sci. 2020 Dec;133:131-135. doi: 10.1016/j.rvsc.2020.08.018. Epub 2020 Sep 2.
This study investigated the relationship between train-of-four (TOF) or double burst (DBS) ratios (T4:T1 or B2:B1) and twitch (T1) or burst (B1) magnitudes during the recovery from rocuronium-induced neuromuscular block in dogs and cats. The main hypothesis was that TOF or DBS ratios recover after the recovery of T1 or B1, and hence high ratio levels are sensitive indicators of restoration of the neuromuscular function. Six anesthetized dogs and six anesthetized cats received 0.5 mg/kg of rocuronium intravenously. The amplitudes of T1 or B1 were measured with mechanomyography during neuromuscular block until the neuromuscular function recovered fully. The TOF or DBS ratio was recorded concurrently. In dogs, recovery of T1 and B1 preceded the recovery of the TOF and DBS ratios, and T1 and B1 were always ≥90% of recovery when the respective ratio reached 0.9. In contrast, T1 was still depressed in 5/6 cats when the TOF ratio reached 0.9. At that moment, T1 was 72.5 ± 19.8% of recovery. Similarly, the DBS ratio returned to 0.9 when B1 was still <90% in 3/6 cats of recovery. The TOF and DBS fade in dogs consistently disappeared after the magnitude of T1 or B1 were restored, and hence, ratios ≥0.9 are a sensitive indicator that the neuromuscular function recovered. Our observation in cats however show that the spontaneous recovery of neither the TOF nor the DBS ratio of 0.9 can reliably exclude residual block, as the magnitude of T1 or B1 was still depressed in several instances.
本研究旨在探讨犬猫罗库溴铵诱导神经肌肉阻滞恢复过程中，四个成串刺激（TOF）或双短强直刺激（DBS）比值（T4:T1 或 B2:B1）与肌颤搐（T1）或强直刺激（B1）幅度之间的关系。主要假设是，TOF 或 DBS 比值在 T1 或 B1 恢复后恢复，因此高比值水平是神经肌肉功能恢复的敏感指标。6 只麻醉犬和 6 只麻醉猫静脉注射 0.5mg/kg 罗库溴铵。在神经肌肉阻滞期间，通过肌电图测量 T1 或 B1 的幅度，直到神经肌肉功能完全恢复。同时记录 TOF 或 DBS 比值。在犬中，T1 和 B1 的恢复先于 TOF 和 DBS 比值的恢复，并且当各自的比值达到 0.9 时，T1 和 B1 始终≥90%的恢复。相比之下，当 TOF 比值达到 0.9 时，仍有 5/6 只猫的 T1 受到抑制。此时，T1 为恢复的 72.5±19.8%。同样，当恢复过程中 B1 仍<90%时，3/6 只猫的 DBS 比值恢复到 0.9。犬的 TOF 和 DBS 衰减在 T1 或 B1 幅度恢复后始终消失，因此比值≥0.9 是神经肌肉功能恢复的敏感指标。然而，我们在猫中的观察表明，TOF 或 DBS 比值为 0.9 的自发恢复并不能可靠地排除残留阻滞，因为在几个情况下 T1 或 B1 的幅度仍受到抑制。
