The Emmes Company, LLC, Rockville, MD 20850, USA.
The Emmes Company, LLC, Rockville, MD 20850, USA.
Drug Alcohol Depend. 2020 Dec 1;217:108293. doi: 10.1016/j.drugalcdep.2020.108293. Epub 2020 Sep 15.
To investigate associations between substance dependence and obesity.
Obesity (body mass index ≥ 30 kg/m) status and the status of dependence on heroin, stimulant, marijuana, nicotine and alcohol (past-month status for nicotine and past-year status for all others) were identified from the U.S. National Survey on Drug Use and Health (NSDUH, 2015-2017) datasets. SAS Surveylogistic regression was used to estimate adjusted odds ratio (AOR) for the association between each substance dependence and obesity, adjusting for potentially confounding effects of sociodemographic factors and health condition.
It was estimated that 10.6 % of noninstitutional U.S. residents aged 12 years or older were nicotine-dependent, 3.0 % alcohol-dependent, 1.0 % marijuana-dependent, 0.6 % stimulant-dependent, and 0.2 % heroin-dependent. Heroin-dependent individuals had 59 % lower odds of obesity relative to their non-dependent counterparts (AOR = 0.41; 95 % CI: 0.28-0.60; p < 0.0001). Lower odds of obesity were also noted for marijuana-dependent (AOR = 0.64; 95 % CI: 0.56-0.73; p < 0.0001), nicotine-dependent (AOR = 0.68; 95 % CI: 0.64-0.72; p < 0.0001) and alcohol-dependent (AOR = 0.77, 95 % CI: 0.69-0.84; p < 0.0001) individuals, but not statistically significant for stimulant-dependent individuals (AOR = 0.84; 95 % CI: 0.68-1.02; p = 0.0825).
Heroin, marijuana, nicotine and alcohol dependence were associated with lower odds of obesity than their non-dependence counterparts. Main findings based on 2015-2017 NSDUH are consistent with findings from our prior report based on clinical trials data from National Institute on Drug Abuse Clinical Trials Network, and other epidemiological evidence in the literature. These findings can alert substance abuse treatment professionals to monitor weight change, especially among weight-concerned substance abusers.
探讨物质依赖与肥胖的关系。
从美国国家药物使用与健康调查（NSDUH，2015-2017 年）数据集中确定肥胖（体重指数≥30kg/m）状况和对海洛因、兴奋剂、大麻、尼古丁和酒精的依赖状况（尼古丁为过去一个月的状况，其他所有物质为过去一年的状况）。采用 SAS 调查逻辑回归来估计每种物质依赖与肥胖之间关联的调整后优势比（AOR），并调整社会人口因素和健康状况的潜在混杂影响。
据估计，12 岁及以上非住院的美国居民中，有 10.6%尼古丁依赖，3.0%酒精依赖，1.0%大麻依赖，0.6%兴奋剂依赖，0.2%海洛因依赖。与非依赖者相比，海洛因依赖者肥胖的可能性低 59%（AOR=0.41；95%CI：0.28-0.60；p<0.0001）。大麻依赖者（AOR=0.64；95%CI：0.56-0.73；p<0.0001）、尼古丁依赖者（AOR=0.68；95%CI：0.64-0.72；p<0.0001）和酒精依赖者（AOR=0.77，95%CI：0.69-0.84；p<0.0001）肥胖的可能性也较低，但兴奋剂依赖者（AOR=0.84；95%CI：0.68-1.02；p=0.0825）差异无统计学意义。
与非依赖者相比，海洛因、大麻、尼古丁和酒精依赖者肥胖的可能性较低。基于 2015-2017 年 NSDUH 的主要发现与我们基于国家药物滥用研究所临床试验网络的临床试验数据的先前报告以及文献中的其他流行病学证据一致。这些发现可以提醒药物滥用治疗专业人员监测体重变化，尤其是在关注体重的药物滥用者中。
